Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying new potential bone strength genes.

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Autores principales:	Basel M. Al-Barghouthi, Larry D. Mesner, Gina M. Calabrese, Daniel Brooks, Steven M. Tommasini, Mary L. Bouxsein, Mark C. Horowitz, Clifford J. Rosen, Kevin Nguyen, Samuel Haddox, Emily A. Farber, Suna Onengut-Gumuscu, Daniel Pomp, Charles R. Farber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e2ac2ef78f74d52bdfce93123908f3a
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spelling	oai:doaj.org-article:4e2ac2ef78f74d52bdfce93123908f3a2021-12-02T17:34:38ZSystems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength10.1038/s41467-021-23649-02041-1723https://doaj.org/article/4e2ac2ef78f74d52bdfce93123908f3a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23649-0https://doaj.org/toc/2041-1723Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying new potential bone strength genes.Basel M. Al-BarghouthiLarry D. MesnerGina M. CalabreseDaniel BrooksSteven M. TommasiniMary L. BouxseinMark C. HorowitzClifford J. RosenKevin NguyenSamuel HaddoxEmily A. FarberSuna Onengut-GumuscuDaniel PompCharles R. FarberNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Basel M. Al-Barghouthi Larry D. Mesner Gina M. Calabrese Daniel Brooks Steven M. Tommasini Mary L. Bouxsein Mark C. Horowitz Clifford J. Rosen Kevin Nguyen Samuel Haddox Emily A. Farber Suna Onengut-Gumuscu Daniel Pomp Charles R. Farber Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
description	Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying new potential bone strength genes.
format	article
author	Basel M. Al-Barghouthi Larry D. Mesner Gina M. Calabrese Daniel Brooks Steven M. Tommasini Mary L. Bouxsein Mark C. Horowitz Clifford J. Rosen Kevin Nguyen Samuel Haddox Emily A. Farber Suna Onengut-Gumuscu Daniel Pomp Charles R. Farber
author_facet	Basel M. Al-Barghouthi Larry D. Mesner Gina M. Calabrese Daniel Brooks Steven M. Tommasini Mary L. Bouxsein Mark C. Horowitz Clifford J. Rosen Kevin Nguyen Samuel Haddox Emily A. Farber Suna Onengut-Gumuscu Daniel Pomp Charles R. Farber
author_sort	Basel M. Al-Barghouthi
title	Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
title_short	Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
title_full	Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
title_fullStr	Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
title_full_unstemmed	Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
title_sort	systems genetics in diversity outbred mice inform bmd gwas and identify determinants of bone strength
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e2ac2ef78f74d52bdfce93123908f3a
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Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

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