<italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow

ABSTRACT The fungus Paracoccidioides is a prevalent human pathogen endemic to South America. The genus is composed of five species. In this report, we use 37 whole-genome sequences to study the allocation of genetic variation in Paracoccidioides. We tested three genome-wide predictions of advanced s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Heidi Mavengere, Kathleen Mattox, Marcus M. Teixeira, Victoria E. Sepúlveda, Oscar M. Gomez, Orville Hernandez, Juan McEwen, Daniel R. Matute
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	speciation gene exchange hidden Markov model (HMM) introgression Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4e2c0e9e476d43c3884e4a66dca15383
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4e2c0e9e476d43c3884e4a66dca15383
record_format	dspace
spelling	oai:doaj.org-article:4e2c0e9e476d43c3884e4a66dca153832021-11-15T15:55:44Z<italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow10.1128/mBio.01999-202150-7511https://doaj.org/article/4e2c0e9e476d43c3884e4a66dca153832020-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01999-20https://doaj.org/toc/2150-7511ABSTRACT The fungus Paracoccidioides is a prevalent human pathogen endemic to South America. The genus is composed of five species. In this report, we use 37 whole-genome sequences to study the allocation of genetic variation in Paracoccidioides. We tested three genome-wide predictions of advanced speciation, namely, that all species should be reciprocally monophyletic, that species pairs should be highly differentiated along the whole genome, and that there should be low rates of interspecific gene exchange. We find support for these three hypotheses. Species pairs with older divergences show no evidence of gene exchange, while more recently diverged species pairs show evidence of modest rates of introgression. Our results indicate that as divergence progresses, species boundaries become less porous among Paracoccidioides species. Our results suggest that species in Paracoccidioides are at different stages along the divergence continuum. IMPORTANCE Paracoccidioides is the causal agent of a systemic mycosis in Latin America. Most of the inference of the evolutionary history of Paracoccidioides has used only a few molecular markers. In this report, we evaluate the extent of genome divergence among Paracoccidioides species and study the possibility of interspecific gene exchange. We find that all species are highly differentiated. We also find that the amount of gene flow between species is low and in some cases is even completely absent in spite of geographic overlap. Our study constitutes a systematic effort to identify species boundaries in fungal pathogens and to determine the extent of gene exchange among fungal species.Heidi MavengereKathleen MattoxMarcus M. TeixeiraVictoria E. SepúlvedaOscar M. GomezOrville HernandezJuan McEwenDaniel R. MatuteAmerican Society for Microbiologyarticlespeciationgene exchangehidden Markov model (HMM)introgressionMicrobiologyQR1-502ENmBio, Vol 11, Iss 6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	speciation gene exchange hidden Markov model (HMM) introgression Microbiology QR1-502
spellingShingle	speciation gene exchange hidden Markov model (HMM) introgression Microbiology QR1-502 Heidi Mavengere Kathleen Mattox Marcus M. Teixeira Victoria E. Sepúlveda Oscar M. Gomez Orville Hernandez Juan McEwen Daniel R. Matute <italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow
description	ABSTRACT The fungus Paracoccidioides is a prevalent human pathogen endemic to South America. The genus is composed of five species. In this report, we use 37 whole-genome sequences to study the allocation of genetic variation in Paracoccidioides. We tested three genome-wide predictions of advanced speciation, namely, that all species should be reciprocally monophyletic, that species pairs should be highly differentiated along the whole genome, and that there should be low rates of interspecific gene exchange. We find support for these three hypotheses. Species pairs with older divergences show no evidence of gene exchange, while more recently diverged species pairs show evidence of modest rates of introgression. Our results indicate that as divergence progresses, species boundaries become less porous among Paracoccidioides species. Our results suggest that species in Paracoccidioides are at different stages along the divergence continuum. IMPORTANCE Paracoccidioides is the causal agent of a systemic mycosis in Latin America. Most of the inference of the evolutionary history of Paracoccidioides has used only a few molecular markers. In this report, we evaluate the extent of genome divergence among Paracoccidioides species and study the possibility of interspecific gene exchange. We find that all species are highly differentiated. We also find that the amount of gene flow between species is low and in some cases is even completely absent in spite of geographic overlap. Our study constitutes a systematic effort to identify species boundaries in fungal pathogens and to determine the extent of gene exchange among fungal species.
format	article
author	Heidi Mavengere Kathleen Mattox Marcus M. Teixeira Victoria E. Sepúlveda Oscar M. Gomez Orville Hernandez Juan McEwen Daniel R. Matute
author_facet	Heidi Mavengere Kathleen Mattox Marcus M. Teixeira Victoria E. Sepúlveda Oscar M. Gomez Orville Hernandez Juan McEwen Daniel R. Matute
author_sort	Heidi Mavengere
title	<italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow
title_short	<italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow
title_full	<italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow
title_fullStr	<italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow
title_full_unstemmed	<italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow
title_sort	<italic toggle="yes">paracoccidioides</italic> genomes reflect high levels of species divergence and little interspecific gene flow
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/4e2c0e9e476d43c3884e4a66dca15383
work_keys_str_mv	AT heidimavengere italictoggleyesparacoccidioidesitalicgenomesreflecthighlevelsofspeciesdivergenceandlittleinterspecificgeneflow AT kathleenmattox italictoggleyesparacoccidioidesitalicgenomesreflecthighlevelsofspeciesdivergenceandlittleinterspecificgeneflow AT marcusmteixeira italictoggleyesparacoccidioidesitalicgenomesreflecthighlevelsofspeciesdivergenceandlittleinterspecificgeneflow AT victoriaesepulveda italictoggleyesparacoccidioidesitalicgenomesreflecthighlevelsofspeciesdivergenceandlittleinterspecificgeneflow AT oscarmgomez italictoggleyesparacoccidioidesitalicgenomesreflecthighlevelsofspeciesdivergenceandlittleinterspecificgeneflow AT orvillehernandez italictoggleyesparacoccidioidesitalicgenomesreflecthighlevelsofspeciesdivergenceandlittleinterspecificgeneflow AT juanmcewen italictoggleyesparacoccidioidesitalicgenomesreflecthighlevelsofspeciesdivergenceandlittleinterspecificgeneflow AT danielrmatute italictoggleyesparacoccidioidesitalicgenomesreflecthighlevelsofspeciesdivergenceandlittleinterspecificgeneflow
_version_	1718427147504189440

<italic toggle="yes">Paracoccidioides</italic> Genomes Reflect High Levels of Species Divergence and Little Interspecific Gene Flow

Ejemplares similares