Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

Senescence induction is known to induce stable proliferation arrest. Here, the authors show that sustained PARP inhibition promotes a reversible p53-independent senescence, and that PARP inhibition is synthetic lethal when combined with senolytic agents in pre-clinical models of ovarian and breast c...

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Autores principales: Hubert Fleury, Nicolas Malaquin, Véronique Tu, Sophie Gilbert, Aurélie Martinez, Marc-Alexandre Olivier, Alexandre Sauriol, Laudine Communal, Kim Leclerc-Desaulniers, Euridice Carmona, Diane Provencher, Anne-Marie Mes-Masson, Francis Rodier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/4e2c1618e64c4bbe831260ba6926f628
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Sumario:Senescence induction is known to induce stable proliferation arrest. Here, the authors show that sustained PARP inhibition promotes a reversible p53-independent senescence, and that PARP inhibition is synthetic lethal when combined with senolytic agents in pre-clinical models of ovarian and breast cancer.

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