Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

Senescence induction is known to induce stable proliferation arrest. Here, the authors show that sustained PARP inhibition promotes a reversible p53-independent senescence, and that PARP inhibition is synthetic lethal when combined with senolytic agents in pre-clinical models of ovarian and breast c...

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Autores principales:	Hubert Fleury, Nicolas Malaquin, Véronique Tu, Sophie Gilbert, Aurélie Martinez, Marc-Alexandre Olivier, Alexandre Sauriol, Laudine Communal, Kim Leclerc-Desaulniers, Euridice Carmona, Diane Provencher, Anne-Marie Mes-Masson, Francis Rodier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e2c1618e64c4bbe831260ba6926f628
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spelling	oai:doaj.org-article:4e2c1618e64c4bbe831260ba6926f6282021-12-02T14:38:39ZExploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence10.1038/s41467-019-10460-12041-1723https://doaj.org/article/4e2c1618e64c4bbe831260ba6926f6282019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10460-1https://doaj.org/toc/2041-1723Senescence induction is known to induce stable proliferation arrest. Here, the authors show that sustained PARP inhibition promotes a reversible p53-independent senescence, and that PARP inhibition is synthetic lethal when combined with senolytic agents in pre-clinical models of ovarian and breast cancer.Hubert FleuryNicolas MalaquinVéronique TuSophie GilbertAurélie MartinezMarc-Alexandre OlivierAlexandre SauriolLaudine CommunalKim Leclerc-DesaulniersEuridice CarmonaDiane ProvencherAnne-Marie Mes-MassonFrancis RodierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hubert Fleury Nicolas Malaquin Véronique Tu Sophie Gilbert Aurélie Martinez Marc-Alexandre Olivier Alexandre Sauriol Laudine Communal Kim Leclerc-Desaulniers Euridice Carmona Diane Provencher Anne-Marie Mes-Masson Francis Rodier Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
description	Senescence induction is known to induce stable proliferation arrest. Here, the authors show that sustained PARP inhibition promotes a reversible p53-independent senescence, and that PARP inhibition is synthetic lethal when combined with senolytic agents in pre-clinical models of ovarian and breast cancer.
format	article
author	Hubert Fleury Nicolas Malaquin Véronique Tu Sophie Gilbert Aurélie Martinez Marc-Alexandre Olivier Alexandre Sauriol Laudine Communal Kim Leclerc-Desaulniers Euridice Carmona Diane Provencher Anne-Marie Mes-Masson Francis Rodier
author_facet	Hubert Fleury Nicolas Malaquin Véronique Tu Sophie Gilbert Aurélie Martinez Marc-Alexandre Olivier Alexandre Sauriol Laudine Communal Kim Leclerc-Desaulniers Euridice Carmona Diane Provencher Anne-Marie Mes-Masson Francis Rodier
author_sort	Hubert Fleury
title	Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
title_short	Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
title_full	Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
title_fullStr	Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
title_full_unstemmed	Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
title_sort	exploiting interconnected synthetic lethal interactions between parp inhibition and cancer cell reversible senescence
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4e2c1618e64c4bbe831260ba6926f628
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Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

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