Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review

Jeffrey Wischhusen,1 Uneeb Qureshi,2 Macario Camacho31School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 2United States Public Health Service, Indian Health Service, Uniformed Services University, Bethesda, MD, USA; 3Department of Otolaryngology, Tripler Arm...

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Autores principales:	Wischhusen J, Qureshi U, Camacho M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	LAUP Uvulopalatoplasty Outcomes Complications Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/4e2ec4c51a274537ad4382fe0e4e9556
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spelling	oai:doaj.org-article:4e2ec4c51a274537ad4382fe0e4e95562021-12-02T05:59:20ZLaser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review1179-1608https://doaj.org/article/4e2ec4c51a274537ad4382fe0e4e95562019-05-01T00:00:00Zhttps://www.dovepress.com/laser-assisted-uvulopalatoplasty-laup-complications-and-side-effects-a-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Jeffrey Wischhusen,1 Uneeb Qureshi,2 Macario Camacho31School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 2United States Public Health Service, Indian Health Service, Uniformed Services University, Bethesda, MD, USA; 3Department of Otolaryngology, Tripler Army Medical Center, Honolulu, HI, USAObjective: Laser-assisted uvulopalatoplasty (LAUP) has been used as a treatment option for snoring and obstructive sleep apnea for almost three decades. It has been previously reported that some patient’s sleep-disordered breathing worsened following surgery. The aim of this paper is to further elucidate the specific complications of LAUP.Data sources: A systematic search of the electronic databases MEDLINE/PubMed, Google Scholar, and Embase.Review methods: The PRISMA statement was followed. Databases were searched from inception through September 2, 2018. The following search was applied to MEDLINE/PubMed ((laser AND uvul*) OR (LAUP) OR (LAVP) OR (laser AND (apnea OR apnoea OR sleep))).Results: Forty-two studies with a mean follow-up of 16.1 months reported complications on 3,093 total patients who underwent LAUP. The percentages and associated complications of LAUP are as follows: bleeding (2.6%), candidiasis (0.3%), dryness (7.2%), dysgeusia (0.3%), dysosmia (0.2%), globus sensation (8.2%), surgical site infection (1.3%), velopharyngeal (VP) insufficiency (3.9%), and VP stenosis (1.6%). The mean duration of patient-reported pain in studies that reported pain was 11.65 days. Only globus and VP insufficiency had a significant incidence compared with either the general population or the post-oropharyngeal surgery population with relative risks of 1.48 and 2.25, respectively. Overall, there were approximately 26 complications per 100 patients who underwent LAUP.Conclusion: LAUP is associated with a statistically significant rate of VP insufficiency and globus sensation; however, studies lack details of surgical approaches, suggesting that in a population identified as good candidates, a tissue-sparing approach may result in fewer complications.Keywords: LAUP, uvulopalatoplasty, outcomes, complicationsWischhusen JQureshi UCamacho MDove Medical PressarticleLAUPUvulopalatoplastyOutcomesComplicationsPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 11, Pp 59-67 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	LAUP Uvulopalatoplasty Outcomes Complications Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	LAUP Uvulopalatoplasty Outcomes Complications Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Wischhusen J Qureshi U Camacho M Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review
description	Jeffrey Wischhusen,1 Uneeb Qureshi,2 Macario Camacho31School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 2United States Public Health Service, Indian Health Service, Uniformed Services University, Bethesda, MD, USA; 3Department of Otolaryngology, Tripler Army Medical Center, Honolulu, HI, USAObjective: Laser-assisted uvulopalatoplasty (LAUP) has been used as a treatment option for snoring and obstructive sleep apnea for almost three decades. It has been previously reported that some patient’s sleep-disordered breathing worsened following surgery. The aim of this paper is to further elucidate the specific complications of LAUP.Data sources: A systematic search of the electronic databases MEDLINE/PubMed, Google Scholar, and Embase.Review methods: The PRISMA statement was followed. Databases were searched from inception through September 2, 2018. The following search was applied to MEDLINE/PubMed ((laser AND uvul*) OR (LAUP) OR (LAVP) OR (laser AND (apnea OR apnoea OR sleep))).Results: Forty-two studies with a mean follow-up of 16.1 months reported complications on 3,093 total patients who underwent LAUP. The percentages and associated complications of LAUP are as follows: bleeding (2.6%), candidiasis (0.3%), dryness (7.2%), dysgeusia (0.3%), dysosmia (0.2%), globus sensation (8.2%), surgical site infection (1.3%), velopharyngeal (VP) insufficiency (3.9%), and VP stenosis (1.6%). The mean duration of patient-reported pain in studies that reported pain was 11.65 days. Only globus and VP insufficiency had a significant incidence compared with either the general population or the post-oropharyngeal surgery population with relative risks of 1.48 and 2.25, respectively. Overall, there were approximately 26 complications per 100 patients who underwent LAUP.Conclusion: LAUP is associated with a statistically significant rate of VP insufficiency and globus sensation; however, studies lack details of surgical approaches, suggesting that in a population identified as good candidates, a tissue-sparing approach may result in fewer complications.Keywords: LAUP, uvulopalatoplasty, outcomes, complications
format	article
author	Wischhusen J Qureshi U Camacho M
author_facet	Wischhusen J Qureshi U Camacho M
author_sort	Wischhusen J
title	Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review
title_short	Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review
title_full	Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review
title_fullStr	Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review
title_full_unstemmed	Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review
title_sort	laser-assisted uvulopalatoplasty (laup) complications and side effects: a systematic review
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/4e2ec4c51a274537ad4382fe0e4e9556
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_version_	1718400109221249024

Laser-assisted uvulopalatoplasty (LAUP) complications and side effects: a systematic review

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