Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections.
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/4e335be474d843e98cc83a148898811a |
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| Sumario: | Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections. |
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