Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker

Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections.

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Autores principales:	João L. Carvalho-de-Souza, Francisco Bezanilla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e335be474d843e98cc83a148898811a
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spelling	oai:doaj.org-article:4e335be474d843e98cc83a148898811a2021-12-02T17:01:58ZNoncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker10.1038/s41467-019-11545-72041-1723https://doaj.org/article/4e335be474d843e98cc83a148898811a2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11545-7https://doaj.org/toc/2041-1723Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections.João L. Carvalho-de-SouzaFrancisco BezanillaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q João L. Carvalho-de-Souza Francisco Bezanilla Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
description	Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections.
format	article
author	João L. Carvalho-de-Souza Francisco Bezanilla
author_facet	João L. Carvalho-de-Souza Francisco Bezanilla
author_sort	João L. Carvalho-de-Souza
title	Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
title_short	Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
title_full	Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
title_fullStr	Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
title_full_unstemmed	Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
title_sort	noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of shaker
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4e335be474d843e98cc83a148898811a
work_keys_str_mv	AT joaolcarvalhodesouza noncanonicalmechanismofvoltagesensorcouplingtoporerevealedbytandemdimersofshaker AT franciscobezanilla noncanonicalmechanismofvoltagesensorcouplingtoporerevealedbytandemdimersofshaker
_version_	1718381966911340544

Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker

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