Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections.
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Autores principales: | João L. Carvalho-de-Souza, Francisco Bezanilla |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/4e335be474d843e98cc83a148898811a |
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