Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker

Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections.

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Detalles Bibliográficos
Autores principales: João L. Carvalho-de-Souza, Francisco Bezanilla
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/4e335be474d843e98cc83a148898811a
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