Triple test screening for Down syndrome: an Egyptian-tailored study.

<h4>Background</h4>The incidence of Down syndrome (DS) in Egypt varies between 1:555 and 1:770 and its screening by triple test is becoming increasingly popular nowadays. Results, however, seem inaccurate due to the lack of Egyptian-specific information needed for risk calculation and a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hazem S Abou-Youssef, Manal M Kamal, Dina A Mehaney
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e3971e8d2804bbc83786df4a9a34ffa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4e3971e8d2804bbc83786df4a9a34ffa
record_format	dspace
spelling	oai:doaj.org-article:4e3971e8d2804bbc83786df4a9a34ffa2021-11-25T05:55:52ZTriple test screening for Down syndrome: an Egyptian-tailored study.1932-620310.1371/journal.pone.0110370https://doaj.org/article/4e3971e8d2804bbc83786df4a9a34ffa2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110370https://doaj.org/toc/1932-6203<h4>Background</h4>The incidence of Down syndrome (DS) in Egypt varies between 1:555 and 1:770 and its screening by triple test is becoming increasingly popular nowadays. Results, however, seem inaccurate due to the lack of Egyptian-specific information needed for risk calculation and a clear policy for programme implementation. Our study aimed at calculation and validation of the triple marker medians used in screening Egyptian females as well as to recommend programme conventions to unify screening in this country.<h4>Methods</h4>The study was conducted on 668 Egyptian women, in weeks 15-20 of pregnancy as proven by sonar. Chorionic gonadotropin (CG), α-fetoprotein (AFP) and unconjugated oestriol (uE3) were measured on Siemens Immulite analyzer. Medians of the three parameters were calculated, regressed against gestational age (GA) and weighted by the number of participants/week. Equations were derived to adjust each parameter to the maternal weight and were centered on the median Egyptian weight. Prisca software was fed with the above data, multiples-of-median (MoM) and DS risks were calculated and the screening performance was evaluated at a mid-trimester risk cutoff of 1:270.<h4>Results</h4>Log-linear [AFP/uE3 = 10(A+BGA)] and exponential equations [CG = Ae (B*GA)] were derived and the regressed medians were found to follow similar patterns to other Asian and Western medians. Oestriol was always lowest (even halved) while CG and AFP were intermediate. A linear reciprocal model best fitted weight distribution among Egyptians and successfully adjusted each parameter to a weight of 78.2 kg. Epidemiological monitoring of these recommendations revealed satisfactory performance in terms of 6.7% initial positive rate and 1.00 grand MoM.<h4>Conclusions</h4>Adoption of the above recommendations is hoped to pave the way to a successful DS screening programme tailored to Egyptian peculiarities.Hazem S Abou-YoussefManal M KamalDina A MehaneyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110370 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hazem S Abou-Youssef Manal M Kamal Dina A Mehaney Triple test screening for Down syndrome: an Egyptian-tailored study.
description	<h4>Background</h4>The incidence of Down syndrome (DS) in Egypt varies between 1:555 and 1:770 and its screening by triple test is becoming increasingly popular nowadays. Results, however, seem inaccurate due to the lack of Egyptian-specific information needed for risk calculation and a clear policy for programme implementation. Our study aimed at calculation and validation of the triple marker medians used in screening Egyptian females as well as to recommend programme conventions to unify screening in this country.<h4>Methods</h4>The study was conducted on 668 Egyptian women, in weeks 15-20 of pregnancy as proven by sonar. Chorionic gonadotropin (CG), α-fetoprotein (AFP) and unconjugated oestriol (uE3) were measured on Siemens Immulite analyzer. Medians of the three parameters were calculated, regressed against gestational age (GA) and weighted by the number of participants/week. Equations were derived to adjust each parameter to the maternal weight and were centered on the median Egyptian weight. Prisca software was fed with the above data, multiples-of-median (MoM) and DS risks were calculated and the screening performance was evaluated at a mid-trimester risk cutoff of 1:270.<h4>Results</h4>Log-linear [AFP/uE3 = 10(A+BGA)] and exponential equations [CG = Ae (B*GA)] were derived and the regressed medians were found to follow similar patterns to other Asian and Western medians. Oestriol was always lowest (even halved) while CG and AFP were intermediate. A linear reciprocal model best fitted weight distribution among Egyptians and successfully adjusted each parameter to a weight of 78.2 kg. Epidemiological monitoring of these recommendations revealed satisfactory performance in terms of 6.7% initial positive rate and 1.00 grand MoM.<h4>Conclusions</h4>Adoption of the above recommendations is hoped to pave the way to a successful DS screening programme tailored to Egyptian peculiarities.
format	article
author	Hazem S Abou-Youssef Manal M Kamal Dina A Mehaney
author_facet	Hazem S Abou-Youssef Manal M Kamal Dina A Mehaney
author_sort	Hazem S Abou-Youssef
title	Triple test screening for Down syndrome: an Egyptian-tailored study.
title_short	Triple test screening for Down syndrome: an Egyptian-tailored study.
title_full	Triple test screening for Down syndrome: an Egyptian-tailored study.
title_fullStr	Triple test screening for Down syndrome: an Egyptian-tailored study.
title_full_unstemmed	Triple test screening for Down syndrome: an Egyptian-tailored study.
title_sort	triple test screening for down syndrome: an egyptian-tailored study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/4e3971e8d2804bbc83786df4a9a34ffa
work_keys_str_mv	AT hazemsabouyoussef tripletestscreeningfordownsyndromeanegyptiantailoredstudy AT manalmkamal tripletestscreeningfordownsyndromeanegyptiantailoredstudy AT dinaamehaney tripletestscreeningfordownsyndromeanegyptiantailoredstudy
_version_	1718414336825753600

Triple test screening for Down syndrome: an Egyptian-tailored study.

Ejemplares similares