Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.

<h4>Background</h4>Recent decades have witnessed an increase in mean maternal age at childbirth in most high-resourced countries. Advanced maternal age has been associated with several adverse maternal and perinatal outcomes. Although there are many studies on this topic, data from large...

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Autores principales:	Louise C Kenny, Tina Lavender, Roseanne McNamee, Sinéad M O'Neill, Tracey Mills, Ali S Khashan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e3b20a0131a42869da6bb11843e44fc
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spelling	oai:doaj.org-article:4e3b20a0131a42869da6bb11843e44fc2021-11-18T07:56:51ZAdvanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.1932-620310.1371/journal.pone.0056583https://doaj.org/article/4e3b20a0131a42869da6bb11843e44fc2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23437176/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recent decades have witnessed an increase in mean maternal age at childbirth in most high-resourced countries. Advanced maternal age has been associated with several adverse maternal and perinatal outcomes. Although there are many studies on this topic, data from large contemporary population-based cohorts that controls for demographic variables known to influence perinatal outcomes is limited.<h4>Methods</h4>We performed a population-based cohort study using data on all singleton births in 2004-2008 from the North Western Perinatal Survey based at The University of Manchester, UK. We compared pregnancy outcomes in women aged 30-34, 35-39 and ≥40 years with women aged 20-29 years using log-linear binomial regression. Models were adjusted for parity, ethnicity, social deprivation score and body mass index.<h4>Results</h4>The final study cohort consisted of 215,344 births; 122,307 mothers (54.19%) were aged 20-29 years, 62,371(27.63%) were aged 30-34 years, 33,966(15.05%) were aged 35-39 years and 7,066(3.13%) were aged ≥40 years. Women aged 40+ at delivery were at increased risk of stillbirth (RR = 1.83, [95% CI 1.37-2.43]), pre-term (RR = 1.25, [95% CI: 1.14-1.36]) and very pre-term birth (RR = 1.29, [95% CI:1.08-1.55]), Macrosomia (RR = 1.31, [95% CI: 1.12-1.54]), extremely large for gestational age (RR = 1.40, [95% CI: 1.25-1.58]) and Caesarean delivery (RR = 1.83, [95% CI: 1.77-1.90]).<h4>Conclusions</h4>Advanced maternal age is associated with a range of adverse pregnancy outcomes. These risks are independent of parity and remain after adjusting for the ameliorating effects of higher socioeconomic status. The data from this large contemporary cohort will be of interest to healthcare providers and women and will facilitate evidence based counselling of older expectant mothers.Louise C KennyTina LavenderRoseanne McNameeSinéad M O'NeillTracey MillsAli S KhashanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56583 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Louise C Kenny Tina Lavender Roseanne McNamee Sinéad M O'Neill Tracey Mills Ali S Khashan Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.
description	<h4>Background</h4>Recent decades have witnessed an increase in mean maternal age at childbirth in most high-resourced countries. Advanced maternal age has been associated with several adverse maternal and perinatal outcomes. Although there are many studies on this topic, data from large contemporary population-based cohorts that controls for demographic variables known to influence perinatal outcomes is limited.<h4>Methods</h4>We performed a population-based cohort study using data on all singleton births in 2004-2008 from the North Western Perinatal Survey based at The University of Manchester, UK. We compared pregnancy outcomes in women aged 30-34, 35-39 and ≥40 years with women aged 20-29 years using log-linear binomial regression. Models were adjusted for parity, ethnicity, social deprivation score and body mass index.<h4>Results</h4>The final study cohort consisted of 215,344 births; 122,307 mothers (54.19%) were aged 20-29 years, 62,371(27.63%) were aged 30-34 years, 33,966(15.05%) were aged 35-39 years and 7,066(3.13%) were aged ≥40 years. Women aged 40+ at delivery were at increased risk of stillbirth (RR = 1.83, [95% CI 1.37-2.43]), pre-term (RR = 1.25, [95% CI: 1.14-1.36]) and very pre-term birth (RR = 1.29, [95% CI:1.08-1.55]), Macrosomia (RR = 1.31, [95% CI: 1.12-1.54]), extremely large for gestational age (RR = 1.40, [95% CI: 1.25-1.58]) and Caesarean delivery (RR = 1.83, [95% CI: 1.77-1.90]).<h4>Conclusions</h4>Advanced maternal age is associated with a range of adverse pregnancy outcomes. These risks are independent of parity and remain after adjusting for the ameliorating effects of higher socioeconomic status. The data from this large contemporary cohort will be of interest to healthcare providers and women and will facilitate evidence based counselling of older expectant mothers.
format	article
author	Louise C Kenny Tina Lavender Roseanne McNamee Sinéad M O'Neill Tracey Mills Ali S Khashan
author_facet	Louise C Kenny Tina Lavender Roseanne McNamee Sinéad M O'Neill Tracey Mills Ali S Khashan
author_sort	Louise C Kenny
title	Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.
title_short	Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.
title_full	Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.
title_fullStr	Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.
title_full_unstemmed	Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.
title_sort	advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4e3b20a0131a42869da6bb11843e44fc
work_keys_str_mv	AT louiseckenny advancedmaternalageandadversepregnancyoutcomeevidencefromalargecontemporarycohort AT tinalavender advancedmaternalageandadversepregnancyoutcomeevidencefromalargecontemporarycohort AT roseannemcnamee advancedmaternalageandadversepregnancyoutcomeevidencefromalargecontemporarycohort AT sineadmoneill advancedmaternalageandadversepregnancyoutcomeevidencefromalargecontemporarycohort AT traceymills advancedmaternalageandadversepregnancyoutcomeevidencefromalargecontemporarycohort AT aliskhashan advancedmaternalageandadversepregnancyoutcomeevidencefromalargecontemporarycohort
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Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort.

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