Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation

There are numerous evaluations of natural products, of which majority are food bioactives, performed up to date for their various health beneficial activities via targeting specific proteins. However, the direct identification of a targeted protein remains unexplored for natural occurring compounds....

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Autores principales:	Guliang Yang, Haiyan Zhong, Xinxin Xia, Zhiwen Qi, Chengzhang Wang, Shiming Li
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	PROTAC Ligand Natural products Target binding Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/4e3b3fa7827c47bb94ef853f8ea1da52
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spelling	oai:doaj.org-article:4e3b3fa7827c47bb94ef853f8ea1da522021-11-28T04:31:42ZPotential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation2213-453010.1016/j.fshw.2021.11.001https://doaj.org/article/4e3b3fa7827c47bb94ef853f8ea1da522022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213453021000951https://doaj.org/toc/2213-4530There are numerous evaluations of natural products, of which majority are food bioactives, performed up to date for their various health beneficial activities via targeting specific proteins. However, the direct identification of a targeted protein remains unexplored for natural occurring compounds. Proteolysis targeting chimera (PROTAC) is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway. As the agents in protein degradation dependent on ubiquitin ligase, the bifunctional molecule connects the target protein ligand and E3 ligase ligand together via an appropriate linker. It is highly selective and efficient to induce the ubiquitin-mediated degradation of targeted binding proteins. Therefore, it has been demonstrated that the PROTAC technology has broad application in the modulation of the target protein level. In this review, we outlined the advances in PROTAC combined molecule compounds, summarized its quantitative structure-activity relationship, and finally reviewed the methods applied in identifying the target proteins of natural products. We hope it will provide an insightful application of PROTAC techniques in the target protein identification of natural products including food bioactive molecules.Guliang YangHaiyan ZhongXinxin XiaZhiwen QiChengzhang WangShiming LiKeAi Communications Co., Ltd.articlePROTACLigandNatural productsTarget bindingNutrition. Foods and food supplyTX341-641ENFood Science and Human Wellness, Vol 11, Iss 2, Pp 199-207 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	PROTAC Ligand Natural products Target binding Nutrition. Foods and food supply TX341-641
spellingShingle	PROTAC Ligand Natural products Target binding Nutrition. Foods and food supply TX341-641 Guliang Yang Haiyan Zhong Xinxin Xia Zhiwen Qi Chengzhang Wang Shiming Li Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
description	There are numerous evaluations of natural products, of which majority are food bioactives, performed up to date for their various health beneficial activities via targeting specific proteins. However, the direct identification of a targeted protein remains unexplored for natural occurring compounds. Proteolysis targeting chimera (PROTAC) is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway. As the agents in protein degradation dependent on ubiquitin ligase, the bifunctional molecule connects the target protein ligand and E3 ligase ligand together via an appropriate linker. It is highly selective and efficient to induce the ubiquitin-mediated degradation of targeted binding proteins. Therefore, it has been demonstrated that the PROTAC technology has broad application in the modulation of the target protein level. In this review, we outlined the advances in PROTAC combined molecule compounds, summarized its quantitative structure-activity relationship, and finally reviewed the methods applied in identifying the target proteins of natural products. We hope it will provide an insightful application of PROTAC techniques in the target protein identification of natural products including food bioactive molecules.
format	article
author	Guliang Yang Haiyan Zhong Xinxin Xia Zhiwen Qi Chengzhang Wang Shiming Li
author_facet	Guliang Yang Haiyan Zhong Xinxin Xia Zhiwen Qi Chengzhang Wang Shiming Li
author_sort	Guliang Yang
title	Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
title_short	Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
title_full	Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
title_fullStr	Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
title_full_unstemmed	Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
title_sort	potential application of proteolysis targeting chimera (protac) modification technology in natural products for their targeted protein degradation
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/4e3b3fa7827c47bb94ef853f8ea1da52
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Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation

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