SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

The oncogenic activity of Hexokinase 2, the first rate-limiting enzyme of glycolysis, requires its mitochondrial localization. Here, the authors show that SUMOylation of hexokinase 2 disrupts its binding to mitochondria and protects cells from tumorigenesis in prostate cancer.

Guardado en:

Detalles Bibliográficos
Autores principales:	Xun Shangguan, Jianli He, Zehua Ma, Weiwei zhang, Yiyi Ji, Kai Shen, Zhiying Yue, Wenyu Li, Zhixiang Xin, Quan Zheng, Ying Cao, Jiahua Pan, Baijun Dong, Jinke Cheng, Qi Wang, Wei Xue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e3e924854294e17bd2cd16091505acc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4e3e924854294e17bd2cd16091505acc
record_format	dspace
spelling	oai:doaj.org-article:4e3e924854294e17bd2cd16091505acc2021-12-02T11:44:50ZSUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis10.1038/s41467-021-22163-72041-1723https://doaj.org/article/4e3e924854294e17bd2cd16091505acc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22163-7https://doaj.org/toc/2041-1723The oncogenic activity of Hexokinase 2, the first rate-limiting enzyme of glycolysis, requires its mitochondrial localization. Here, the authors show that SUMOylation of hexokinase 2 disrupts its binding to mitochondria and protects cells from tumorigenesis in prostate cancer.Xun ShangguanJianli HeZehua MaWeiwei zhangYiyi JiKai ShenZhiying YueWenyu LiZhixiang XinQuan ZhengYing CaoJiahua PanBaijun DongJinke ChengQi WangWei XueNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xun Shangguan Jianli He Zehua Ma Weiwei zhang Yiyi Ji Kai Shen Zhiying Yue Wenyu Li Zhixiang Xin Quan Zheng Ying Cao Jiahua Pan Baijun Dong Jinke Cheng Qi Wang Wei Xue SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
description	The oncogenic activity of Hexokinase 2, the first rate-limiting enzyme of glycolysis, requires its mitochondrial localization. Here, the authors show that SUMOylation of hexokinase 2 disrupts its binding to mitochondria and protects cells from tumorigenesis in prostate cancer.
format	article
author	Xun Shangguan Jianli He Zehua Ma Weiwei zhang Yiyi Ji Kai Shen Zhiying Yue Wenyu Li Zhixiang Xin Quan Zheng Ying Cao Jiahua Pan Baijun Dong Jinke Cheng Qi Wang Wei Xue
author_facet	Xun Shangguan Jianli He Zehua Ma Weiwei zhang Yiyi Ji Kai Shen Zhiying Yue Wenyu Li Zhixiang Xin Quan Zheng Ying Cao Jiahua Pan Baijun Dong Jinke Cheng Qi Wang Wei Xue
author_sort	Xun Shangguan
title	SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
title_short	SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
title_full	SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
title_fullStr	SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
title_full_unstemmed	SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
title_sort	sumoylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e3e924854294e17bd2cd16091505acc
work_keys_str_mv	AT xunshangguan sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT jianlihe sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT zehuama sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT weiweizhang sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT yiyiji sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT kaishen sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT zhiyingyue sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT wenyuli sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT zhixiangxin sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT quanzheng sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT yingcao sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT jiahuapan sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT baijundong sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT jinkecheng sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT qiwang sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis AT weixue sumoylationcontrolsthebindingofhexokinase2tomitochondriaandprotectsagainstprostatecancertumorigenesis
_version_	1718395279336538112

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

Ejemplares similares