Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

The mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight junctions, allowing rapid bacterial dissemination f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Laura C. Jacques, Stavros Panagiotou, Murielle Baltazar, Madikay Senghore, Shadia Khandaker, Rong Xu, Laura Bricio-Moreno, Marie Yang, Christopher G. Dowson, Dean B. Everett, Daniel R. Neill, Aras Kadioglu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e3fa97f73434e33a5cdb4df33c7b5d6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4e3fa97f73434e33a5cdb4df33c7b5d6
record_format	dspace
spelling	oai:doaj.org-article:4e3fa97f73434e33a5cdb4df33c7b5d62021-12-02T14:42:15ZIncreased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin10.1038/s41467-020-15751-62041-1723https://doaj.org/article/4e3fa97f73434e33a5cdb4df33c7b5d62020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15751-6https://doaj.org/toc/2041-1723The mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight junctions, allowing rapid bacterial dissemination from the respiratory tract into the blood.Laura C. JacquesStavros PanagiotouMurielle BaltazarMadikay SenghoreShadia KhandakerRong XuLaura Bricio-MorenoMarie YangChristopher G. DowsonDean B. EverettDaniel R. NeillAras KadiogluNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura C. Jacques Stavros Panagiotou Murielle Baltazar Madikay Senghore Shadia Khandaker Rong Xu Laura Bricio-Moreno Marie Yang Christopher G. Dowson Dean B. Everett Daniel R. Neill Aras Kadioglu Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
description	The mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight junctions, allowing rapid bacterial dissemination from the respiratory tract into the blood.
format	article
author	Laura C. Jacques Stavros Panagiotou Murielle Baltazar Madikay Senghore Shadia Khandaker Rong Xu Laura Bricio-Moreno Marie Yang Christopher G. Dowson Dean B. Everett Daniel R. Neill Aras Kadioglu
author_facet	Laura C. Jacques Stavros Panagiotou Murielle Baltazar Madikay Senghore Shadia Khandaker Rong Xu Laura Bricio-Moreno Marie Yang Christopher G. Dowson Dean B. Everett Daniel R. Neill Aras Kadioglu
author_sort	Laura C. Jacques
title	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_short	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_full	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_fullStr	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_full_unstemmed	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_sort	increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4e3fa97f73434e33a5cdb4df33c7b5d6
work_keys_str_mv	AT lauracjacques increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT stavrospanagiotou increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT muriellebaltazar increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT madikaysenghore increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT shadiakhandaker increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT rongxu increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT laurabriciomoreno increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT marieyang increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT christophergdowson increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT deanbeverett increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT danielrneill increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT araskadioglu increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin
_version_	1718389748044660736

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

Ejemplares similares