Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

Whole tissue RNA profiling can help identify altered molecular pathways underlying neurodegenerative disease, but often masks cell type-specific transcriptional changes. Here, the authors compare transcriptomes of neurons, astrocytes, and microglia from Alzheimer's disease model brains and iden...

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Autores principales:	Karpagam Srinivasan, Brad A. Friedman, Jessica L. Larson, Benjamin E. Lauffer, Leonard D. Goldstein, Laurie L. Appling, Jovencio Borneo, Chungkee Poon, Terence Ho, Fang Cai, Pascal Steiner, Marcel P. van der Brug, Zora Modrusan, Joshua S. Kaminker, David V. Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e42c47333a545e9888f87129654ccf7
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spelling	oai:doaj.org-article:4e42c47333a545e9888f87129654ccf72021-12-02T17:33:07ZUntangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses10.1038/ncomms112952041-1723https://doaj.org/article/4e42c47333a545e9888f87129654ccf72016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11295https://doaj.org/toc/2041-1723Whole tissue RNA profiling can help identify altered molecular pathways underlying neurodegenerative disease, but often masks cell type-specific transcriptional changes. Here, the authors compare transcriptomes of neurons, astrocytes, and microglia from Alzheimer's disease model brains and identify hundreds of cell-type specific changes.Karpagam SrinivasanBrad A. FriedmanJessica L. LarsonBenjamin E. LaufferLeonard D. GoldsteinLaurie L. ApplingJovencio BorneoChungkee PoonTerence HoFang CaiPascal SteinerMarcel P. van der BrugZora ModrusanJoshua S. KaminkerDavid V. HansenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karpagam Srinivasan Brad A. Friedman Jessica L. Larson Benjamin E. Lauffer Leonard D. Goldstein Laurie L. Appling Jovencio Borneo Chungkee Poon Terence Ho Fang Cai Pascal Steiner Marcel P. van der Brug Zora Modrusan Joshua S. Kaminker David V. Hansen Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
description	Whole tissue RNA profiling can help identify altered molecular pathways underlying neurodegenerative disease, but often masks cell type-specific transcriptional changes. Here, the authors compare transcriptomes of neurons, astrocytes, and microglia from Alzheimer's disease model brains and identify hundreds of cell-type specific changes.
format	article
author	Karpagam Srinivasan Brad A. Friedman Jessica L. Larson Benjamin E. Lauffer Leonard D. Goldstein Laurie L. Appling Jovencio Borneo Chungkee Poon Terence Ho Fang Cai Pascal Steiner Marcel P. van der Brug Zora Modrusan Joshua S. Kaminker David V. Hansen
author_facet	Karpagam Srinivasan Brad A. Friedman Jessica L. Larson Benjamin E. Lauffer Leonard D. Goldstein Laurie L. Appling Jovencio Borneo Chungkee Poon Terence Ho Fang Cai Pascal Steiner Marcel P. van der Brug Zora Modrusan Joshua S. Kaminker David V. Hansen
author_sort	Karpagam Srinivasan
title	Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
title_short	Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
title_full	Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
title_fullStr	Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
title_full_unstemmed	Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
title_sort	untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4e42c47333a545e9888f87129654ccf7
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Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

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