Coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome

Limited data exist on the association between breast cancer treatments and coronary artery disease anatomy, particularly in males. We describe an unusual case of diffuse coronary ectasia in a man with breast cancer presenting with acute coronary syndrome (ACS). A 66-year-old man with breast cancer o...

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Autores principales:	Dana C Johnson, Luay Rifai, Parag V Patel
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2016
Materias:	acute coronary syndrome breast cancer coronary ectasia paclitaxel percutaneous coronary intervention Medicine R
Acceso en línea:	https://doaj.org/article/4e430c3a14af4413a49e411bffdaf4a1
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spelling	oai:doaj.org-article:4e430c3a14af4413a49e411bffdaf4a12021-12-02T16:37:41ZCoronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome2231-07702249-446410.4103/2231-0770.191450https://doaj.org/article/4e430c3a14af4413a49e411bffdaf4a12016-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.191450https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Limited data exist on the association between breast cancer treatments and coronary artery disease anatomy, particularly in males. We describe an unusual case of diffuse coronary ectasia in a man with breast cancer presenting with acute coronary syndrome (ACS). A 66-year-old man with breast cancer on paclitaxel, tamoxifen, and carboplatin chemotherapy regimen, presents with new onset chest pain. Electrocardiogram reveals anterolateral ST-segment depressions and elevated troponin I level. Emergent angiography revealed grossly ectatic coronary arteries with a total thrombotic occlusion of the mid right coronary artery. Serial intracoronary aspiration thrombectomy revealed fragments of red thrombus. Intracoronary tenectaplase was ultimately administered to restore perfusion. The patient clinically improved and warfarin was added to his cardiac regimen. Laboratory work up for connective tissue disease was negative. Although paclitaxel has been implicated in coronary artery neointima and media proliferation in the setting of drug-eluting stents, we believe our case is the first to describe massive coronary ectasia with significant thrombus burden requiring complex coronary intervention and thrombolysis in the setting of breast cancer therapy in a man.Dana C JohnsonLuay RifaiParag V PatelThieme Medical and Scientific Publishers Pvt. Ltd.articleacute coronary syndromebreast cancercoronary ectasiapaclitaxelpercutaneous coronary interventionMedicineRENAvicenna Journal of Medicine, Vol 06, Iss 04, Pp 120-123 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute coronary syndrome breast cancer coronary ectasia paclitaxel percutaneous coronary intervention Medicine R
spellingShingle	acute coronary syndrome breast cancer coronary ectasia paclitaxel percutaneous coronary intervention Medicine R Dana C Johnson Luay Rifai Parag V Patel Coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome
description	Limited data exist on the association between breast cancer treatments and coronary artery disease anatomy, particularly in males. We describe an unusual case of diffuse coronary ectasia in a man with breast cancer presenting with acute coronary syndrome (ACS). A 66-year-old man with breast cancer on paclitaxel, tamoxifen, and carboplatin chemotherapy regimen, presents with new onset chest pain. Electrocardiogram reveals anterolateral ST-segment depressions and elevated troponin I level. Emergent angiography revealed grossly ectatic coronary arteries with a total thrombotic occlusion of the mid right coronary artery. Serial intracoronary aspiration thrombectomy revealed fragments of red thrombus. Intracoronary tenectaplase was ultimately administered to restore perfusion. The patient clinically improved and warfarin was added to his cardiac regimen. Laboratory work up for connective tissue disease was negative. Although paclitaxel has been implicated in coronary artery neointima and media proliferation in the setting of drug-eluting stents, we believe our case is the first to describe massive coronary ectasia with significant thrombus burden requiring complex coronary intervention and thrombolysis in the setting of breast cancer therapy in a man.
format	article
author	Dana C Johnson Luay Rifai Parag V Patel
author_facet	Dana C Johnson Luay Rifai Parag V Patel
author_sort	Dana C Johnson
title	Coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome
title_short	Coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome
title_full	Coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome
title_fullStr	Coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome
title_full_unstemmed	Coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome
title_sort	coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2016
url	https://doaj.org/article/4e430c3a14af4413a49e411bffdaf4a1
work_keys_str_mv	AT danacjohnson coronaryectasiainamanonbreastcancertherapypresentingwithacutecoronarysyndrome AT luayrifai coronaryectasiainamanonbreastcancertherapypresentingwithacutecoronarysyndrome AT paragvpatel coronaryectasiainamanonbreastcancertherapypresentingwithacutecoronarysyndrome
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Coronary ectasia in a man on breast cancer therapy presenting with acute coronary syndrome

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