CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide

CD229 is expressed on the surface of multiple myeloma cells, as well as B and T lymphocytes. Here, the authors engineer CD229-specific CAR T cells and, using patient samples and mouse models, show that treatment with these cells reduces tumour burden and results in limited targeting of T cells.

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Autores principales:	Sabarinath V. Radhakrishnan, Tim Luetkens, Sandra D. Scherer, Patricia Davis, Erica R. Vander Mause, Michael L. Olson, Sara Yousef, Jens Panse, Yasmina Abdiche, K. David Li, Rodney R. Miles, William Matsui, Alana L. Welm, Djordje Atanackovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e432057e84c4bb2853dee941535a21e
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spelling	oai:doaj.org-article:4e432057e84c4bb2853dee941535a21e2021-12-02T15:37:13ZCD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide10.1038/s41467-020-14619-z2041-1723https://doaj.org/article/4e432057e84c4bb2853dee941535a21e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14619-zhttps://doaj.org/toc/2041-1723CD229 is expressed on the surface of multiple myeloma cells, as well as B and T lymphocytes. Here, the authors engineer CD229-specific CAR T cells and, using patient samples and mouse models, show that treatment with these cells reduces tumour burden and results in limited targeting of T cells.Sabarinath V. RadhakrishnanTim LuetkensSandra D. SchererPatricia DavisErica R. Vander MauseMichael L. OlsonSara YousefJens PanseYasmina AbdicheK. David LiRodney R. MilesWilliam MatsuiAlana L. WelmDjordje AtanackovicNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sabarinath V. Radhakrishnan Tim Luetkens Sandra D. Scherer Patricia Davis Erica R. Vander Mause Michael L. Olson Sara Yousef Jens Panse Yasmina Abdiche K. David Li Rodney R. Miles William Matsui Alana L. Welm Djordje Atanackovic CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide
description	CD229 is expressed on the surface of multiple myeloma cells, as well as B and T lymphocytes. Here, the authors engineer CD229-specific CAR T cells and, using patient samples and mouse models, show that treatment with these cells reduces tumour burden and results in limited targeting of T cells.
format	article
author	Sabarinath V. Radhakrishnan Tim Luetkens Sandra D. Scherer Patricia Davis Erica R. Vander Mause Michael L. Olson Sara Yousef Jens Panse Yasmina Abdiche K. David Li Rodney R. Miles William Matsui Alana L. Welm Djordje Atanackovic
author_facet	Sabarinath V. Radhakrishnan Tim Luetkens Sandra D. Scherer Patricia Davis Erica R. Vander Mause Michael L. Olson Sara Yousef Jens Panse Yasmina Abdiche K. David Li Rodney R. Miles William Matsui Alana L. Welm Djordje Atanackovic
author_sort	Sabarinath V. Radhakrishnan
title	CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide
title_short	CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide
title_full	CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide
title_fullStr	CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide
title_full_unstemmed	CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide
title_sort	cd229 car t cells eliminate multiple myeloma and tumor propagating cells without fratricide
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4e432057e84c4bb2853dee941535a21e
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CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide

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