CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide
CD229 is expressed on the surface of multiple myeloma cells, as well as B and T lymphocytes. Here, the authors engineer CD229-specific CAR T cells and, using patient samples and mouse models, show that treatment with these cells reduces tumour burden and results in limited targeting of T cells.
Guardado en:
Autores principales: | Sabarinath V. Radhakrishnan, Tim Luetkens, Sandra D. Scherer, Patricia Davis, Erica R. Vander Mause, Michael L. Olson, Sara Yousef, Jens Panse, Yasmina Abdiche, K. David Li, Rodney R. Miles, William Matsui, Alana L. Welm, Djordje Atanackovic |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/4e432057e84c4bb2853dee941535a21e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Acta Nº229
por: Banco Central de Chile
Publicado: (2019) -
Resolución 229(X): Distribución del ingreso = Resolution 229(X): Income distribution = Résolution 229(X) Répartition du revenu
Publicado: (2014) -
Targeting MAGE-C1/CT7 expression increases cell sensitivity to the proteasome inhibitor bortezomib in multiple myeloma cell lines.
por: Fabricio de Carvalho, et al.
Publicado: (2011) -
The outer-membrane protein MafA of Neisseria meningitidis constitutes a novel protein secretion pathway specific for the fratricide protein MafB
por: Jesús Arenas, et al.
Publicado: (2020) -
Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials
por: Sarah L. Warnes, et al.
Publicado: (2015)