Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection

Abstract The value of image based texture features as a powerful method to predict prognosis and assist clinical management in cancer patients has been established recently. However, texture analysis using histograms and grey-level co-occurrence matrix in pancreas cancer patients has rarely been rep...

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Autores principales:	Gabin Yun, Young Hoon Kim, Yoon Jin Lee, Bohyoung Kim, Jin-Hyeok Hwang, Dong Joon Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e43619850274e0880cf4ee0e469901d
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spelling	oai:doaj.org-article:4e43619850274e0880cf4ee0e469901d2021-12-02T16:08:26ZTumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection10.1038/s41598-018-25627-x2045-2322https://doaj.org/article/4e43619850274e0880cf4ee0e469901d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25627-xhttps://doaj.org/toc/2045-2322Abstract The value of image based texture features as a powerful method to predict prognosis and assist clinical management in cancer patients has been established recently. However, texture analysis using histograms and grey-level co-occurrence matrix in pancreas cancer patients has rarely been reported. We aimed to analyze the association of survival outcomes with texture features in pancreas head cancer patients. Eighty-eight pancreas head cancer patients who underwent preoperative CT images followed by curative resection were included. Texture features using different filter values were obtained. The texture features of average, contrast, correlation, and standard deviation with no filter, and fine to medium filter values as well as the presence of nodal metastasis were significantly different between the recurred (n = 70, 79.5%) and non-recurred group (n = 18, 20.5%). In the multivariate Cox regression analysis, lower standard deviation and contrast and higher correlation with lower average value representing homogenous texture were significantly associated with poorer DFS (disease free survival), along with the presence of lymph node metastasis. Texture parameters from routinely performed pre-operative CT images could be used as an independent imaging tool for predicting the prognosis in pancreas head cancer patients who underwent curative resection.Gabin YunYoung Hoon KimYoon Jin LeeBohyoung KimJin-Hyeok HwangDong Joon ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gabin Yun Young Hoon Kim Yoon Jin Lee Bohyoung Kim Jin-Hyeok Hwang Dong Joon Choi Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection
description	Abstract The value of image based texture features as a powerful method to predict prognosis and assist clinical management in cancer patients has been established recently. However, texture analysis using histograms and grey-level co-occurrence matrix in pancreas cancer patients has rarely been reported. We aimed to analyze the association of survival outcomes with texture features in pancreas head cancer patients. Eighty-eight pancreas head cancer patients who underwent preoperative CT images followed by curative resection were included. Texture features using different filter values were obtained. The texture features of average, contrast, correlation, and standard deviation with no filter, and fine to medium filter values as well as the presence of nodal metastasis were significantly different between the recurred (n = 70, 79.5%) and non-recurred group (n = 18, 20.5%). In the multivariate Cox regression analysis, lower standard deviation and contrast and higher correlation with lower average value representing homogenous texture were significantly associated with poorer DFS (disease free survival), along with the presence of lymph node metastasis. Texture parameters from routinely performed pre-operative CT images could be used as an independent imaging tool for predicting the prognosis in pancreas head cancer patients who underwent curative resection.
format	article
author	Gabin Yun Young Hoon Kim Yoon Jin Lee Bohyoung Kim Jin-Hyeok Hwang Dong Joon Choi
author_facet	Gabin Yun Young Hoon Kim Yoon Jin Lee Bohyoung Kim Jin-Hyeok Hwang Dong Joon Choi
author_sort	Gabin Yun
title	Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection
title_short	Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection
title_full	Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection
title_fullStr	Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection
title_full_unstemmed	Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection
title_sort	tumor heterogeneity of pancreas head cancer assessed by ct texture analysis: association with survival outcomes after curative resection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4e43619850274e0880cf4ee0e469901d
work_keys_str_mv	AT gabinyun tumorheterogeneityofpancreasheadcancerassessedbycttextureanalysisassociationwithsurvivaloutcomesaftercurativeresection AT younghoonkim tumorheterogeneityofpancreasheadcancerassessedbycttextureanalysisassociationwithsurvivaloutcomesaftercurativeresection AT yoonjinlee tumorheterogeneityofpancreasheadcancerassessedbycttextureanalysisassociationwithsurvivaloutcomesaftercurativeresection AT bohyoungkim tumorheterogeneityofpancreasheadcancerassessedbycttextureanalysisassociationwithsurvivaloutcomesaftercurativeresection AT jinhyeokhwang tumorheterogeneityofpancreasheadcancerassessedbycttextureanalysisassociationwithsurvivaloutcomesaftercurativeresection AT dongjoonchoi tumorheterogeneityofpancreasheadcancerassessedbycttextureanalysisassociationwithsurvivaloutcomesaftercurativeresection
_version_	1718384465969938432

Tumor heterogeneity of pancreas head cancer assessed by CT texture analysis: association with survival outcomes after curative resection

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