Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.

During postnatal development hippocampal dentate granule cells (GCs) often extend dendrites from the basal pole of their cell bodies into the hilar region. These so-called hilar basal dendrites (hBD) usually regress with maturation. However, hBDs may persist in a subset of mature GCs under certain c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Denise Becker, Laurent Maximilian Willems, Matej Vnencak, Nadine Zahn, Gerlind Schuldt, Peter Jedlicka, Nicola Maggio, Thomas Deller, Andreas Vlachos
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e43bcc0c70c413f985b198429467ffb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4e43bcc0c70c413f985b198429467ffb
record_format	dspace
spelling	oai:doaj.org-article:4e43bcc0c70c413f985b198429467ffb2021-11-18T08:09:46ZFunctional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.1932-620310.1371/journal.pone.0048500https://doaj.org/article/4e43bcc0c70c413f985b198429467ffb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144894/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203During postnatal development hippocampal dentate granule cells (GCs) often extend dendrites from the basal pole of their cell bodies into the hilar region. These so-called hilar basal dendrites (hBD) usually regress with maturation. However, hBDs may persist in a subset of mature GCs under certain conditions (both physiological and pathological). The functional role of these hBD-GCs remains not well understood. Here, we have studied hBD-GCs in mature (≥18 days in vitro) mouse entorhino-hippocampal slice cultures under control conditions and have compared their basic functional properties (basic intrinsic and synaptic properties) and structural properties (dendritic arborisation and spine densities) to those of neighboring GCs without hBDs in the same set of cultures. Except for the presence of hBDs, we did not detect major differences between the two GC populations. Furthermore, paired recordings of neighboring GCs with and without hBDs did not reveal evidence for a heavy aberrant GC-to-GC connectivity. Taken together, our data suggest that in control cultures the presence of hBDs on GCs is neither sufficient to predict alterations in the basic functional and structural properties of these GCs nor indicative of a heavy GC-to-GC connectivity between neighboring GCs.Denise BeckerLaurent Maximilian WillemsMatej VnencakNadine ZahnGerlind SchuldtPeter JedlickaNicola MaggioThomas DellerAndreas VlachosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48500 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Denise Becker Laurent Maximilian Willems Matej Vnencak Nadine Zahn Gerlind Schuldt Peter Jedlicka Nicola Maggio Thomas Deller Andreas Vlachos Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.
description	During postnatal development hippocampal dentate granule cells (GCs) often extend dendrites from the basal pole of their cell bodies into the hilar region. These so-called hilar basal dendrites (hBD) usually regress with maturation. However, hBDs may persist in a subset of mature GCs under certain conditions (both physiological and pathological). The functional role of these hBD-GCs remains not well understood. Here, we have studied hBD-GCs in mature (≥18 days in vitro) mouse entorhino-hippocampal slice cultures under control conditions and have compared their basic functional properties (basic intrinsic and synaptic properties) and structural properties (dendritic arborisation and spine densities) to those of neighboring GCs without hBDs in the same set of cultures. Except for the presence of hBDs, we did not detect major differences between the two GC populations. Furthermore, paired recordings of neighboring GCs with and without hBDs did not reveal evidence for a heavy aberrant GC-to-GC connectivity. Taken together, our data suggest that in control cultures the presence of hBDs on GCs is neither sufficient to predict alterations in the basic functional and structural properties of these GCs nor indicative of a heavy GC-to-GC connectivity between neighboring GCs.
format	article
author	Denise Becker Laurent Maximilian Willems Matej Vnencak Nadine Zahn Gerlind Schuldt Peter Jedlicka Nicola Maggio Thomas Deller Andreas Vlachos
author_facet	Denise Becker Laurent Maximilian Willems Matej Vnencak Nadine Zahn Gerlind Schuldt Peter Jedlicka Nicola Maggio Thomas Deller Andreas Vlachos
author_sort	Denise Becker
title	Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.
title_short	Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.
title_full	Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.
title_fullStr	Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.
title_full_unstemmed	Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.
title_sort	functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4e43bcc0c70c413f985b198429467ffb
work_keys_str_mv	AT denisebecker functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures AT laurentmaximilianwillems functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures AT matejvnencak functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures AT nadinezahn functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures AT gerlindschuldt functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures AT peterjedlicka functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures AT nicolamaggio functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures AT thomasdeller functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures AT andreasvlachos functionalandstructuralpropertiesofdentategranulecellswithhilarbasaldendritesinmouseentorhinohippocampalslicecultures
_version_	1718422104392597504

Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.

Ejemplares similares