Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study

Abstract There has been no long-term clinical follow-up data of survivors or victims of sudden cardiac death (SCD). The Taiwan multi-center sudden arrhythmia death syndrome follow-up and clinical study (TFS-SADS) is a collaborative multi-center study with median follow-up time 43 months. In this coh...

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Autores principales:	Pang-Shuo Huang, Jen-Fang Cheng, Wen-Chin Ko, Shu-Hsuan Chang, Tin-Tse Lin, Jien-Jiun Chen, Fu-Chun Chiu, Lian-Yu Lin, Ling-Ping Lai, Jiunn-Lee Lin, Chia-Ti Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e459f3ca8b249a5b19bb1b1af0e02d8
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spelling	oai:doaj.org-article:4e459f3ca8b249a5b19bb1b1af0e02d82021-12-02T15:15:40ZUnique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study10.1038/s41598-021-95975-82045-2322https://doaj.org/article/4e459f3ca8b249a5b19bb1b1af0e02d82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95975-8https://doaj.org/toc/2045-2322Abstract There has been no long-term clinical follow-up data of survivors or victims of sudden cardiac death (SCD). The Taiwan multi-center sudden arrhythmia death syndrome follow-up and clinical study (TFS-SADS) is a collaborative multi-center study with median follow-up time 43 months. In this cohort, the clinical characteristics of these SADS patients were compared with those with ischemic heart disease (IHD). In this SCD cohort, around half (42%) were patients with IHD, which was different from Caucasian SCD cohorts. Among those with normal heart, most had Brugada syndrome (BrS). Compared to those with SADS, patients with IHD were older, more males and more comorbidities, more arrhythmic death, and lower left ventricular ejection fraction. In the long-term follow-up, patients with SADS had a better survival than those with IHD (p < 0.001). In the Cox regression analysis to identify the independent predictors of mortality, older age, lower LVEF, prior myocardial infarction and history of out-of-hospital cardiac arrest were associated with higher mortality and beta blocker use and idiopathic ventricular fibrillation or tachycardia (IVF/IVT) with a better survival during follow-up. History of prior MI was associated with more arrhythmic death. Several distinct features of SCD were found in the Asia–Pacific region, such as higher proportion of SADS, poorer prognosis of LQTS and better prognosis of IVF/IVT. Patients with SADS had a better survival than those with IHD. For those with SADS, patients with channelopathy had a better survival than those with cardiomyopathy.Pang-Shuo HuangJen-Fang ChengWen-Chin KoShu-Hsuan ChangTin-Tse LinJien-Jiun ChenFu-Chun ChiuLian-Yu LinLing-Ping LaiJiunn-Lee LinChia-Ti TsaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pang-Shuo Huang Jen-Fang Cheng Wen-Chin Ko Shu-Hsuan Chang Tin-Tse Lin Jien-Jiun Chen Fu-Chun Chiu Lian-Yu Lin Ling-Ping Lai Jiunn-Lee Lin Chia-Ti Tsai Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study
description	Abstract There has been no long-term clinical follow-up data of survivors or victims of sudden cardiac death (SCD). The Taiwan multi-center sudden arrhythmia death syndrome follow-up and clinical study (TFS-SADS) is a collaborative multi-center study with median follow-up time 43 months. In this cohort, the clinical characteristics of these SADS patients were compared with those with ischemic heart disease (IHD). In this SCD cohort, around half (42%) were patients with IHD, which was different from Caucasian SCD cohorts. Among those with normal heart, most had Brugada syndrome (BrS). Compared to those with SADS, patients with IHD were older, more males and more comorbidities, more arrhythmic death, and lower left ventricular ejection fraction. In the long-term follow-up, patients with SADS had a better survival than those with IHD (p < 0.001). In the Cox regression analysis to identify the independent predictors of mortality, older age, lower LVEF, prior myocardial infarction and history of out-of-hospital cardiac arrest were associated with higher mortality and beta blocker use and idiopathic ventricular fibrillation or tachycardia (IVF/IVT) with a better survival during follow-up. History of prior MI was associated with more arrhythmic death. Several distinct features of SCD were found in the Asia–Pacific region, such as higher proportion of SADS, poorer prognosis of LQTS and better prognosis of IVF/IVT. Patients with SADS had a better survival than those with IHD. For those with SADS, patients with channelopathy had a better survival than those with cardiomyopathy.
format	article
author	Pang-Shuo Huang Jen-Fang Cheng Wen-Chin Ko Shu-Hsuan Chang Tin-Tse Lin Jien-Jiun Chen Fu-Chun Chiu Lian-Yu Lin Ling-Ping Lai Jiunn-Lee Lin Chia-Ti Tsai
author_facet	Pang-Shuo Huang Jen-Fang Cheng Wen-Chin Ko Shu-Hsuan Chang Tin-Tse Lin Jien-Jiun Chen Fu-Chun Chiu Lian-Yu Lin Ling-Ping Lai Jiunn-Lee Lin Chia-Ti Tsai
author_sort	Pang-Shuo Huang
title	Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study
title_short	Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study
title_full	Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study
title_fullStr	Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study
title_full_unstemmed	Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study
title_sort	unique clinical features and long term follow up of survivors of sudden cardiac death in an asian multicenter study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e459f3ca8b249a5b19bb1b1af0e02d8
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Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study

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