Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans

How the genetic background modifies the expression of mutations is a key question that is addressed in this study in the context of seam cell development in Caenorhabditis elegans isolates. One amino acid deletion in a conserved heat shock protein is sufficient to shape phenotype expressivity upon m...

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Autores principales:	Sneha L. Koneru, Mark Hintze, Dimitris Katsanos, Michalis Barkoulas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e46d30d12474282beb7d61ec7f184b5
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spelling	oai:doaj.org-article:4e46d30d12474282beb7d61ec7f184b52021-12-02T15:57:09ZCryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans10.1038/s41467-021-23567-12041-1723https://doaj.org/article/4e46d30d12474282beb7d61ec7f184b52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23567-1https://doaj.org/toc/2041-1723How the genetic background modifies the expression of mutations is a key question that is addressed in this study in the context of seam cell development in Caenorhabditis elegans isolates. One amino acid deletion in a conserved heat shock protein is sufficient to shape phenotype expressivity upon mutation of a GATA transcription factor.Sneha L. KoneruMark HintzeDimitris KatsanosMichalis BarkoulasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sneha L. Koneru Mark Hintze Dimitris Katsanos Michalis Barkoulas Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans
description	How the genetic background modifies the expression of mutations is a key question that is addressed in this study in the context of seam cell development in Caenorhabditis elegans isolates. One amino acid deletion in a conserved heat shock protein is sufficient to shape phenotype expressivity upon mutation of a GATA transcription factor.
format	article
author	Sneha L. Koneru Mark Hintze Dimitris Katsanos Michalis Barkoulas
author_facet	Sneha L. Koneru Mark Hintze Dimitris Katsanos Michalis Barkoulas
author_sort	Sneha L. Koneru
title	Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans
title_short	Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans
title_full	Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans
title_fullStr	Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans
title_full_unstemmed	Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans
title_sort	cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in c. elegans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e46d30d12474282beb7d61ec7f184b5
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Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans

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