Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models

The COVID-19 pandemic represents an unprecedented global emergency. Despite all efforts, COVID-19 remains a threat to public health, due to the complexity of mass vaccination programs, the lack of effective drugs, and the emergence of new variants. A link has recently been found between the risk of...

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Autores principales:	Fabio Magurano, Marzia Sucameli, Pasquale Picone, Matteo Micucci, Melissa Baggieri, Antonella Marchi, Paola Bucci, Silvia Gioacchini, Giorgia Catinella, Gigliola Borgonovo, Sabrina Dallavalle, Domenico Nuzzo, Andrea Pinto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 SARS-CoV2 grapefruit seeds limonoids antioxidant activity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/4e4d650a02d64df0acb1ee569e482833
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spelling	oai:doaj.org-article:4e4d650a02d64df0acb1ee569e4828332021-11-25T16:28:42ZAntioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models10.3390/antiox101117942076-3921https://doaj.org/article/4e4d650a02d64df0acb1ee569e4828332021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1794https://doaj.org/toc/2076-3921The COVID-19 pandemic represents an unprecedented global emergency. Despite all efforts, COVID-19 remains a threat to public health, due to the complexity of mass vaccination programs, the lack of effective drugs, and the emergence of new variants. A link has recently been found between the risk of developing a severe COVID-19 infection and a high level of oxidative stress. In this context, we have focused our attention on natural compounds with the aim of finding molecules capable of acting through a dual virucidal–antioxidant mechanism. In particular, we studied the potential of grapefruit seed extracts (GSE) and their main components, belonging to the class of limonoids. Using chemical and biological approaches including isolation and purification of GSE, antioxidant and virucidal assays, we have shown that grapefruit seed constituents, belonging to the class of limonoids, are endowed with remarkable virucidal, antioxidant and mitoprotective activity.Fabio MaguranoMarzia SucameliPasquale PiconeMatteo MicucciMelissa BaggieriAntonella MarchiPaola BucciSilvia GioacchiniGiorgia CatinellaGigliola BorgonovoSabrina DallavalleDomenico NuzzoAndrea PintoMDPI AGarticleCOVID-19SARS-CoV2grapefruit seedslimonoidsantioxidant activityTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1794, p 1794 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV2 grapefruit seeds limonoids antioxidant activity Therapeutics. Pharmacology RM1-950
spellingShingle	COVID-19 SARS-CoV2 grapefruit seeds limonoids antioxidant activity Therapeutics. Pharmacology RM1-950 Fabio Magurano Marzia Sucameli Pasquale Picone Matteo Micucci Melissa Baggieri Antonella Marchi Paola Bucci Silvia Gioacchini Giorgia Catinella Gigliola Borgonovo Sabrina Dallavalle Domenico Nuzzo Andrea Pinto Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models
description	The COVID-19 pandemic represents an unprecedented global emergency. Despite all efforts, COVID-19 remains a threat to public health, due to the complexity of mass vaccination programs, the lack of effective drugs, and the emergence of new variants. A link has recently been found between the risk of developing a severe COVID-19 infection and a high level of oxidative stress. In this context, we have focused our attention on natural compounds with the aim of finding molecules capable of acting through a dual virucidal–antioxidant mechanism. In particular, we studied the potential of grapefruit seed extracts (GSE) and their main components, belonging to the class of limonoids. Using chemical and biological approaches including isolation and purification of GSE, antioxidant and virucidal assays, we have shown that grapefruit seed constituents, belonging to the class of limonoids, are endowed with remarkable virucidal, antioxidant and mitoprotective activity.
format	article
author	Fabio Magurano Marzia Sucameli Pasquale Picone Matteo Micucci Melissa Baggieri Antonella Marchi Paola Bucci Silvia Gioacchini Giorgia Catinella Gigliola Borgonovo Sabrina Dallavalle Domenico Nuzzo Andrea Pinto
author_facet	Fabio Magurano Marzia Sucameli Pasquale Picone Matteo Micucci Melissa Baggieri Antonella Marchi Paola Bucci Silvia Gioacchini Giorgia Catinella Gigliola Borgonovo Sabrina Dallavalle Domenico Nuzzo Andrea Pinto
author_sort	Fabio Magurano
title	Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models
title_short	Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models
title_full	Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models
title_fullStr	Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models
title_full_unstemmed	Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models
title_sort	antioxidant activity of citrus limonoids and investigation of their virucidal potential against sars-cov-2 in cellular models
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4e4d650a02d64df0acb1ee569e482833
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Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models

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