Clinical features of drug-induced liver failure and related diagnosis and treatment strategies

The incidence of drug-induced liver injury (DILI) has risen considerably in recent years. Drug-induced liver failure tends to have severe conditions, limited therapeutic strategy, and a high mortality rate and should thus be taken seriously by clinicians. N-acetyl-p-aminophenol is the most common c...

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Autor principal:	LAI Rongtao
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Department of Journal of Clinical Hepatology 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/4e50fbc5a70840ccb02f7a21bae0a574
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spelling	oai:doaj.org-article:4e50fbc5a70840ccb02f7a21bae0a5742021-11-17T10:38:51ZClinical features of drug-induced liver failure and related diagnosis and treatment strategies1001-5256https://doaj.org/article/4e50fbc5a70840ccb02f7a21bae0a5742021-11-01T00:00:00Zhttp://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.11.006https://doaj.org/toc/1001-5256The incidence of drug-induced liver injury (DILI) has risen considerably in recent years. Drug-induced liver failure tends to have severe conditions, limited therapeutic strategy, and a high mortality rate and should thus be taken seriously by clinicians. N-acetyl-p-aminophenol is the most common cause of acute liver failure (ALF) in Western countries; for ALF associated with idiosyncratic DILI (iDILI), since there is little in-deep understanding of host susceptibility and pathogenesis, it is difficult to identify ALF caused by iDILI in the early stage, and due to a low rate of spontaneous recovery and poor prognosis, it has become a major indication for emergency liver transplantation in many countries. A comprehensive understanding of the clinical features and prognostic prediction of drug-induced liver failure and the search for new reliable diagnostic methods and effective treatment strategies are of vital importance in reducing the disease burden of drug-induced liver failure. LAI RongtaoEditorial Department of Journal of Clinical HepatologyarticleDiseases of the digestive system. GastroenterologyRC799-869ZHLinchuang Gandanbing Zazhi, Vol 37, Iss 11, Pp 2534-2538 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 LAI Rongtao Clinical features of drug-induced liver failure and related diagnosis and treatment strategies
description	The incidence of drug-induced liver injury (DILI) has risen considerably in recent years. Drug-induced liver failure tends to have severe conditions, limited therapeutic strategy, and a high mortality rate and should thus be taken seriously by clinicians. N-acetyl-p-aminophenol is the most common cause of acute liver failure (ALF) in Western countries; for ALF associated with idiosyncratic DILI (iDILI), since there is little in-deep understanding of host susceptibility and pathogenesis, it is difficult to identify ALF caused by iDILI in the early stage, and due to a low rate of spontaneous recovery and poor prognosis, it has become a major indication for emergency liver transplantation in many countries. A comprehensive understanding of the clinical features and prognostic prediction of drug-induced liver failure and the search for new reliable diagnostic methods and effective treatment strategies are of vital importance in reducing the disease burden of drug-induced liver failure.
format	article
author	LAI Rongtao
author_facet	LAI Rongtao
author_sort	LAI Rongtao
title	Clinical features of drug-induced liver failure and related diagnosis and treatment strategies
title_short	Clinical features of drug-induced liver failure and related diagnosis and treatment strategies
title_full	Clinical features of drug-induced liver failure and related diagnosis and treatment strategies
title_fullStr	Clinical features of drug-induced liver failure and related diagnosis and treatment strategies
title_full_unstemmed	Clinical features of drug-induced liver failure and related diagnosis and treatment strategies
title_sort	clinical features of drug-induced liver failure and related diagnosis and treatment strategies
publisher	Editorial Department of Journal of Clinical Hepatology
publishDate	2021
url	https://doaj.org/article/4e50fbc5a70840ccb02f7a21bae0a574
work_keys_str_mv	AT lairongtao clinicalfeaturesofdruginducedliverfailureandrelateddiagnosisandtreatmentstrategies
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Clinical features of drug-induced liver failure and related diagnosis and treatment strategies

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