Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice
Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown. Endothelial transient receptor potential vanilloid 4 (TRPV4) channels lower pulmonary artery (PA) con...
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Main Authors: | Zdravka Daneva, Matteo Ottolini, Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A Shah, Richard D Minshall, Cheikh I Seye, Victor E Laubach, Brant E Isakson, Swapnil K Sonkusare |
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Format: | article |
Language: | EN |
Published: |
eLife Sciences Publications Ltd
2021
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Online Access: | https://doaj.org/article/4e52c48d21c241c0a4496dbc4db01f8d |
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