Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty

Abstract To examine the association of preoperative opioids and/or benzodiazepines on postoperative outcomes in total knee and hip arthroplasty, we retrospectively compared postoperative outcomes in those prescribed preoperative opioids and/or benzodiazepines versus those who were not who underwent...

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Autores principales:	Lisa V. Doan, Kristoffer Padjen, Deborah Ok, Adam Gover, Jawad Rashid, Bijan Osmani, Shirley Avraham, Jing Wang, Samir Kendale
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e535f8566b64197a988f4f10daed8b0
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spelling	oai:doaj.org-article:4e535f8566b64197a988f4f10daed8b02021-12-02T15:45:31ZRelation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty10.1038/s41598-021-90083-z2045-2322https://doaj.org/article/4e535f8566b64197a988f4f10daed8b02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90083-zhttps://doaj.org/toc/2045-2322Abstract To examine the association of preoperative opioids and/or benzodiazepines on postoperative outcomes in total knee and hip arthroplasty, we retrospectively compared postoperative outcomes in those prescribed preoperative opioids and/or benzodiazepines versus those who were not who underwent elective total knee and hip arthroplasty at a single urban academic institution. Multivariable logistic regression was performed for readmission rate, respiratory failure, infection, and adverse cardiac events. Multivariable zero-truncated negative binomial regression was used for length of stay. After exclusions, there were 4307 adult patients in the study population, 2009 of whom underwent total knee arthroplasty and 2298 of whom underwent total hip arthroplasty. After adjusting for potential confounders, preoperative benzodiazepine use was associated with increased odds of readmission (p < 0.01). Preoperative benzodiazepines were not associated with increased odds of respiratory failure nor increased length of stay. Preoperative opioids were not associated with increased odds of the examined outcomes. There were insufficient numbers of infection and cardiac events for analysis. In this study population, preoperative benzodiazepines were associated with increased odds of readmission. Preoperative opioids were not associated with increased odds of the examined outcomes. Studies are needed to further examine risks associated with preoperative benzodiazepine use.Lisa V. DoanKristoffer PadjenDeborah OkAdam GoverJawad RashidBijan OsmaniShirley AvrahamJing WangSamir KendaleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisa V. Doan Kristoffer Padjen Deborah Ok Adam Gover Jawad Rashid Bijan Osmani Shirley Avraham Jing Wang Samir Kendale Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty
description	Abstract To examine the association of preoperative opioids and/or benzodiazepines on postoperative outcomes in total knee and hip arthroplasty, we retrospectively compared postoperative outcomes in those prescribed preoperative opioids and/or benzodiazepines versus those who were not who underwent elective total knee and hip arthroplasty at a single urban academic institution. Multivariable logistic regression was performed for readmission rate, respiratory failure, infection, and adverse cardiac events. Multivariable zero-truncated negative binomial regression was used for length of stay. After exclusions, there were 4307 adult patients in the study population, 2009 of whom underwent total knee arthroplasty and 2298 of whom underwent total hip arthroplasty. After adjusting for potential confounders, preoperative benzodiazepine use was associated with increased odds of readmission (p < 0.01). Preoperative benzodiazepines were not associated with increased odds of respiratory failure nor increased length of stay. Preoperative opioids were not associated with increased odds of the examined outcomes. There were insufficient numbers of infection and cardiac events for analysis. In this study population, preoperative benzodiazepines were associated with increased odds of readmission. Preoperative opioids were not associated with increased odds of the examined outcomes. Studies are needed to further examine risks associated with preoperative benzodiazepine use.
format	article
author	Lisa V. Doan Kristoffer Padjen Deborah Ok Adam Gover Jawad Rashid Bijan Osmani Shirley Avraham Jing Wang Samir Kendale
author_facet	Lisa V. Doan Kristoffer Padjen Deborah Ok Adam Gover Jawad Rashid Bijan Osmani Shirley Avraham Jing Wang Samir Kendale
author_sort	Lisa V. Doan
title	Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty
title_short	Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty
title_full	Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty
title_fullStr	Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty
title_full_unstemmed	Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty
title_sort	relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e535f8566b64197a988f4f10daed8b0
work_keys_str_mv	AT lisavdoan relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty AT kristofferpadjen relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty AT deborahok relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty AT adamgover relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty AT jawadrashid relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty AT bijanosmani relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty AT shirleyavraham relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty AT jingwang relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty AT samirkendale relationbetweenpreoperativebenzodiazepinesandopioidsonoutcomesaftertotaljointarthroplasty
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Relation between preoperative benzodiazepines and opioids on outcomes after total joint arthroplasty

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