Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population

Abstract Background Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among Chinese overweight/obese population....

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Autores principales:	Ruoyi Liu, Qiao Zhang, Nianchun Peng, Shujing Xu, Miao Zhang, Ying Hu, Zhengyi Chen, Kun Tang, Xi He, Yi Li, Lixin Shi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Irisin Cardiovascular disease Diabetes mellitus Hypertension Dyslipidemia Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/4e571e60126c46c8a383b581ce8b2e1a
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spelling	oai:doaj.org-article:4e571e60126c46c8a383b581ce8b2e1a2021-12-05T12:05:18ZInverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population10.1186/s12872-021-02380-01471-2261https://doaj.org/article/4e571e60126c46c8a383b581ce8b2e1a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02380-0https://doaj.org/toc/1471-2261Abstract Background Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among Chinese overweight/obese population. Methods A total of 98 overweight and 93 obese subjects without clinical treatments were enrolled in this study. Subjects were then divided into two groups, based on the serum irisin level: a low irisin group (1.10–13.44 ng/ml) and a high irisin group (13.49–29.9 ng/ml). The clustering of CVRFs, smoking, diabetes mellitus, dyslipidemia and hypertension, was classified as 0, 1, 2 and ≥ 3 CVRFs. The demographic and baseline clinical characteristics of all participants were collected and serum irisin was measured. Results The high serum irisin group had significantly higher high-density lipoprotein cholesterol but lower fasting plasma glucose than the low serum irisin group. Additionally, the high serum irisin group had a significantly lower prevalence of smoking, diabetes mellitus and dyslipidemia than the low serum irisin group. Increased serum irisin was significantly associated with a reduced risk of smoking and dyslipidemia in both the unadjusted and adjusted models. Furthermore, high serum irisin significantly reduced the risk of the prevalence of 1, 2 and ≥ 3 CVRFs. Conclusions among the Chinese overweight/obese populations, high serum irisin is negatively associated with smoking, dyslipidemia and the clustering of CVRFs. Thus, high serum irisin is potentially associated with a low risk of cardiovascular diseases in the Chinese overweight/obese population.Ruoyi LiuQiao ZhangNianchun PengShujing XuMiao ZhangYing HuZhengyi ChenKun TangXi HeYi LiLixin ShiBMCarticleIrisinCardiovascular diseaseDiabetes mellitusHypertensionDyslipidemiaDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Irisin Cardiovascular disease Diabetes mellitus Hypertension Dyslipidemia Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Irisin Cardiovascular disease Diabetes mellitus Hypertension Dyslipidemia Diseases of the circulatory (Cardiovascular) system RC666-701 Ruoyi Liu Qiao Zhang Nianchun Peng Shujing Xu Miao Zhang Ying Hu Zhengyi Chen Kun Tang Xi He Yi Li Lixin Shi Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population
description	Abstract Background Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among Chinese overweight/obese population. Methods A total of 98 overweight and 93 obese subjects without clinical treatments were enrolled in this study. Subjects were then divided into two groups, based on the serum irisin level: a low irisin group (1.10–13.44 ng/ml) and a high irisin group (13.49–29.9 ng/ml). The clustering of CVRFs, smoking, diabetes mellitus, dyslipidemia and hypertension, was classified as 0, 1, 2 and ≥ 3 CVRFs. The demographic and baseline clinical characteristics of all participants were collected and serum irisin was measured. Results The high serum irisin group had significantly higher high-density lipoprotein cholesterol but lower fasting plasma glucose than the low serum irisin group. Additionally, the high serum irisin group had a significantly lower prevalence of smoking, diabetes mellitus and dyslipidemia than the low serum irisin group. Increased serum irisin was significantly associated with a reduced risk of smoking and dyslipidemia in both the unadjusted and adjusted models. Furthermore, high serum irisin significantly reduced the risk of the prevalence of 1, 2 and ≥ 3 CVRFs. Conclusions among the Chinese overweight/obese populations, high serum irisin is negatively associated with smoking, dyslipidemia and the clustering of CVRFs. Thus, high serum irisin is potentially associated with a low risk of cardiovascular diseases in the Chinese overweight/obese population.
format	article
author	Ruoyi Liu Qiao Zhang Nianchun Peng Shujing Xu Miao Zhang Ying Hu Zhengyi Chen Kun Tang Xi He Yi Li Lixin Shi
author_facet	Ruoyi Liu Qiao Zhang Nianchun Peng Shujing Xu Miao Zhang Ying Hu Zhengyi Chen Kun Tang Xi He Yi Li Lixin Shi
author_sort	Ruoyi Liu
title	Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population
title_short	Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population
title_full	Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population
title_fullStr	Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population
title_full_unstemmed	Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population
title_sort	inverse correlation between serum irisin and cardiovascular risk factors among chinese overweight/obese population
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4e571e60126c46c8a383b581ce8b2e1a
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Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population

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