The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis

Abstract A large number of studies have shown that programmed death-ligand 1 (PD-L1) is abnormally expressed in gliomas. However, the prognostic significance of PD-L1 expression in glioma patients remains unresolved. Accordingly, we conducted a meta-analysis to determine the prognostic role of high...

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Autores principales:	Song Xue, Ge Song, Jinming Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e58c5280fa74b82bf6220c1945f3a66
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spelling	oai:doaj.org-article:4e58c5280fa74b82bf6220c1945f3a662021-12-02T16:07:57ZThe prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis10.1038/s41598-017-04023-x2045-2322https://doaj.org/article/4e58c5280fa74b82bf6220c1945f3a662017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04023-xhttps://doaj.org/toc/2045-2322Abstract A large number of studies have shown that programmed death-ligand 1 (PD-L1) is abnormally expressed in gliomas. However, the prognostic significance of PD-L1 expression in glioma patients remains unresolved. Accordingly, we conducted a meta-analysis to determine the prognostic role of high PD-L1 in patients with glioma. Electronic databases were searched to identify studies evaluating PD-L1 expression and overall survival (OS) in these patients. A total of 6 studies (published in 4 articles) that involved 1052 patients were included. Pooled results showed that high PD-L1 expression was associated with worse OS in glioma patients (HR = 1.30, 95% CI: 1.02–1.65, P = 0.032). Further subgroup analysis indicated that high PD-L1 expression in glioblastoma (GBM) was also associated with worse OS (HR = 1.40, 95% CI: 1.03–1.90, P = 0.030). Conversely, in index subgroup analysis, neither PD-L1 protein (HR = 1.43, 95% CI: 0.97–2.10, P = 0.068) nor gene (HR = 1.20, 95% CI: 0.83–1.74, P = 0.322) expression was significantly associated with OS. PD-L1 may represent a promising biomarker that predicts disease progression in patients with glioma or GBM. However, because of our limited sample size, further prospective or retrospective multi-centre, well-designed studies should be performed to verify this result.Song XueGe SongJinming YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Song Xue Ge Song Jinming Yu The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis
description	Abstract A large number of studies have shown that programmed death-ligand 1 (PD-L1) is abnormally expressed in gliomas. However, the prognostic significance of PD-L1 expression in glioma patients remains unresolved. Accordingly, we conducted a meta-analysis to determine the prognostic role of high PD-L1 in patients with glioma. Electronic databases were searched to identify studies evaluating PD-L1 expression and overall survival (OS) in these patients. A total of 6 studies (published in 4 articles) that involved 1052 patients were included. Pooled results showed that high PD-L1 expression was associated with worse OS in glioma patients (HR = 1.30, 95% CI: 1.02–1.65, P = 0.032). Further subgroup analysis indicated that high PD-L1 expression in glioblastoma (GBM) was also associated with worse OS (HR = 1.40, 95% CI: 1.03–1.90, P = 0.030). Conversely, in index subgroup analysis, neither PD-L1 protein (HR = 1.43, 95% CI: 0.97–2.10, P = 0.068) nor gene (HR = 1.20, 95% CI: 0.83–1.74, P = 0.322) expression was significantly associated with OS. PD-L1 may represent a promising biomarker that predicts disease progression in patients with glioma or GBM. However, because of our limited sample size, further prospective or retrospective multi-centre, well-designed studies should be performed to verify this result.
format	article
author	Song Xue Ge Song Jinming Yu
author_facet	Song Xue Ge Song Jinming Yu
author_sort	Song Xue
title	The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis
title_short	The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis
title_full	The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis
title_fullStr	The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis
title_full_unstemmed	The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis
title_sort	prognostic significance of pd-l1 expression in patients with glioma: a meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4e58c5280fa74b82bf6220c1945f3a66
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The prognostic significance of PD-L1 expression in patients with glioma: A meta-analysis

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