Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis

Abstract Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of...

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Autores principales:	Diana Prieto-Peña, Sara Remuzgo-Martínez, Fernanda Genre, Verónica Pulito-Cueto, Belén Atienza-Mateo, Javier Llorca, Belén Sevilla-Pérez, Norberto Ortego-Centeno, Ana Marquez, Leticia Lera-Gómez, María Teresa Leonardo, Ana Peñalba, Javier Narváez, Luis Martín-Penagos, Emilio Rodrigo, José A. Miranda-Filloy, Luis Caminal-Montero, Paz Collado, Javier Sánchez Pérez, Diego de Argila, Esteban Rubio, Manuel León Luque, Juan María Blanco-Madrigal, Eva Galíndez-Agirregoikoa, Oreste Gualillo, Javier Martín, Santos Castañeda, Ricardo Blanco, Miguel A. González-Gay, Raquel López-Mejías
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e5c12cf144c4687a3cac75fff04094d
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spelling	oai:doaj.org-article:4e5c12cf144c4687a3cac75fff04094d2021-12-02T16:28:51ZRole of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis10.1038/s41598-021-95762-52045-2322https://doaj.org/article/4e5c12cf144c4687a3cac75fff04094d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95762-5https://doaj.org/toc/2045-2322Abstract Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.Diana Prieto-PeñaSara Remuzgo-MartínezFernanda GenreVerónica Pulito-CuetoBelén Atienza-MateoJavier LlorcaBelén Sevilla-PérezNorberto Ortego-CentenoAna MarquezLeticia Lera-GómezMaría Teresa LeonardoAna PeñalbaJavier NarváezLuis Martín-PenagosEmilio RodrigoJosé A. Miranda-FilloyLuis Caminal-MonteroPaz ColladoJavier Sánchez PérezDiego de ArgilaEsteban RubioManuel León LuqueJuan María Blanco-MadrigalEva Galíndez-AgirregoikoaOreste GualilloJavier MartínSantos CastañedaRicardo BlancoMiguel A. González-GayRaquel López-MejíasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Diana Prieto-Peña Sara Remuzgo-Martínez Fernanda Genre Verónica Pulito-Cueto Belén Atienza-Mateo Javier Llorca Belén Sevilla-Pérez Norberto Ortego-Centeno Ana Marquez Leticia Lera-Gómez María Teresa Leonardo Ana Peñalba Javier Narváez Luis Martín-Penagos Emilio Rodrigo José A. Miranda-Filloy Luis Caminal-Montero Paz Collado Javier Sánchez Pérez Diego de Argila Esteban Rubio Manuel León Luque Juan María Blanco-Madrigal Eva Galíndez-Agirregoikoa Oreste Gualillo Javier Martín Santos Castañeda Ricardo Blanco Miguel A. González-Gay Raquel López-Mejías Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis
description	Abstract Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.
format	article
author	Diana Prieto-Peña Sara Remuzgo-Martínez Fernanda Genre Verónica Pulito-Cueto Belén Atienza-Mateo Javier Llorca Belén Sevilla-Pérez Norberto Ortego-Centeno Ana Marquez Leticia Lera-Gómez María Teresa Leonardo Ana Peñalba Javier Narváez Luis Martín-Penagos Emilio Rodrigo José A. Miranda-Filloy Luis Caminal-Montero Paz Collado Javier Sánchez Pérez Diego de Argila Esteban Rubio Manuel León Luque Juan María Blanco-Madrigal Eva Galíndez-Agirregoikoa Oreste Gualillo Javier Martín Santos Castañeda Ricardo Blanco Miguel A. González-Gay Raquel López-Mejías
author_facet	Diana Prieto-Peña Sara Remuzgo-Martínez Fernanda Genre Verónica Pulito-Cueto Belén Atienza-Mateo Javier Llorca Belén Sevilla-Pérez Norberto Ortego-Centeno Ana Marquez Leticia Lera-Gómez María Teresa Leonardo Ana Peñalba Javier Narváez Luis Martín-Penagos Emilio Rodrigo José A. Miranda-Filloy Luis Caminal-Montero Paz Collado Javier Sánchez Pérez Diego de Argila Esteban Rubio Manuel León Luque Juan María Blanco-Madrigal Eva Galíndez-Agirregoikoa Oreste Gualillo Javier Martín Santos Castañeda Ricardo Blanco Miguel A. González-Gay Raquel López-Mejías
author_sort	Diana Prieto-Peña
title	Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis
title_short	Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis
title_full	Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis
title_fullStr	Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis
title_full_unstemmed	Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis
title_sort	role of the il33 and il1rl1 pathway in the pathogenesis of immunoglobulin a vasculitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e5c12cf144c4687a3cac75fff04094d
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Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis

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