Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer

Dynamic regulation in molecular networks including cell cycle regulation and DNA damage response play an important role in cancer. To reveal the feature of cancer malignancy, gene expression and network regulation were profiled in diffuse- and intestinal-type gastric cancer (GC). The results of the...

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Autores principales:	Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer malignancy cell cycle regulation epithelial-mesenchymal transition (EMT) DNA damage response gastric cancer molecular network Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4e60f7fa907f4c9cbf7821e3be16958d
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spelling	oai:doaj.org-article:4e60f7fa907f4c9cbf7821e3be16958d2021-11-25T17:03:59ZCell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer10.3390/cancers132257862072-6694https://doaj.org/article/4e60f7fa907f4c9cbf7821e3be16958d2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5786https://doaj.org/toc/2072-6694Dynamic regulation in molecular networks including cell cycle regulation and DNA damage response play an important role in cancer. To reveal the feature of cancer malignancy, gene expression and network regulation were profiled in diffuse- and intestinal-type gastric cancer (GC). The results of the network analysis with Ingenuity Pathway Analysis (IPA) showed that the activation states of several canonical pathways related to cell cycle regulation were altered. The G<sub>1</sub>/S checkpoint regulation pathway was activated in diffuse-type GC compared to intestinal-type GC, while canonical pathways of the cell cycle control of chromosomal replication, and the cyclin and cell cycle regulation, were activated in intestinal-type GC compared to diffuse-type GC. A canonical pathway on the role of BRCA1 in the DNA damage response was activated in intestinal-type GC compared to diffuse-type GC, where gene expression of BRCA1, which is related to G<sub>1</sub>/S phase transition, was upregulated in intestinal-type GC compared to diffuse-type GC. Several microRNAs (miRNAs), such as mir-10, mir-17, mir-19, mir-194, mir-224, mir-25, mir-34, mir-451 and mir-605, were identified to have direct relationships in the G<sub>1</sub>/S cell cycle checkpoint regulation pathway. Additionally, cell cycle regulation may be altered in epithelial-mesenchymal transition (EMT) conditions. The alterations in the activation states of the pathways related to cell cycle regulation in diffuse- and intestinal-type GC highlighted the significance of cell cycle regulation in EMT.Shihori TanabeSabina QuaderRyuichi OnoHoracio CabralKazuhiko AoyagiAkihiko HiroseHiroshi YokozakiHiroki SasakiMDPI AGarticlecancer malignancycell cycle regulationepithelial-mesenchymal transition (EMT)DNA damage responsegastric cancermolecular networkNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5786, p 5786 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer malignancy cell cycle regulation epithelial-mesenchymal transition (EMT) DNA damage response gastric cancer molecular network Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancer malignancy cell cycle regulation epithelial-mesenchymal transition (EMT) DNA damage response gastric cancer molecular network Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shihori Tanabe Sabina Quader Ryuichi Ono Horacio Cabral Kazuhiko Aoyagi Akihiko Hirose Hiroshi Yokozaki Hiroki Sasaki Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer
description	Dynamic regulation in molecular networks including cell cycle regulation and DNA damage response play an important role in cancer. To reveal the feature of cancer malignancy, gene expression and network regulation were profiled in diffuse- and intestinal-type gastric cancer (GC). The results of the network analysis with Ingenuity Pathway Analysis (IPA) showed that the activation states of several canonical pathways related to cell cycle regulation were altered. The G<sub>1</sub>/S checkpoint regulation pathway was activated in diffuse-type GC compared to intestinal-type GC, while canonical pathways of the cell cycle control of chromosomal replication, and the cyclin and cell cycle regulation, were activated in intestinal-type GC compared to diffuse-type GC. A canonical pathway on the role of BRCA1 in the DNA damage response was activated in intestinal-type GC compared to diffuse-type GC, where gene expression of BRCA1, which is related to G<sub>1</sub>/S phase transition, was upregulated in intestinal-type GC compared to diffuse-type GC. Several microRNAs (miRNAs), such as mir-10, mir-17, mir-19, mir-194, mir-224, mir-25, mir-34, mir-451 and mir-605, were identified to have direct relationships in the G<sub>1</sub>/S cell cycle checkpoint regulation pathway. Additionally, cell cycle regulation may be altered in epithelial-mesenchymal transition (EMT) conditions. The alterations in the activation states of the pathways related to cell cycle regulation in diffuse- and intestinal-type GC highlighted the significance of cell cycle regulation in EMT.
format	article
author	Shihori Tanabe Sabina Quader Ryuichi Ono Horacio Cabral Kazuhiko Aoyagi Akihiko Hirose Hiroshi Yokozaki Hiroki Sasaki
author_facet	Shihori Tanabe Sabina Quader Ryuichi Ono Horacio Cabral Kazuhiko Aoyagi Akihiko Hirose Hiroshi Yokozaki Hiroki Sasaki
author_sort	Shihori Tanabe
title	Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer
title_short	Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer
title_full	Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer
title_fullStr	Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer
title_full_unstemmed	Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer
title_sort	cell cycle regulation and dna damage response networks in diffuse- and intestinal-type gastric cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4e60f7fa907f4c9cbf7821e3be16958d
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Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer

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