Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker

Eph receptor tyrosine kinases and their ephrin ligands mediate cell-cell communication. Here, the authors assess the structure and dynamics of the EphA2 intracellular region and uncover complex effects of phosphorylation within the linker region between EphA2 kinase and SAM domains.

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Detalles Bibliográficos
Autores principales:	Bernhard C. Lechtenberg, Marina P. Gehring, Taylor P. Light, Christopher R. Horne, Mike W. Matsumoto, Kalina Hristova, Elena B. Pasquale
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e61813b18fe47238560b7007035a60e
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spelling	oai:doaj.org-article:4e61813b18fe47238560b7007035a60e2021-12-05T12:22:28ZRegulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker10.1038/s41467-021-27343-z2041-1723https://doaj.org/article/4e61813b18fe47238560b7007035a60e2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27343-zhttps://doaj.org/toc/2041-1723Eph receptor tyrosine kinases and their ephrin ligands mediate cell-cell communication. Here, the authors assess the structure and dynamics of the EphA2 intracellular region and uncover complex effects of phosphorylation within the linker region between EphA2 kinase and SAM domains.Bernhard C. LechtenbergMarina P. GehringTaylor P. LightChristopher R. HorneMike W. MatsumotoKalina HristovaElena B. PasqualeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernhard C. Lechtenberg Marina P. Gehring Taylor P. Light Christopher R. Horne Mike W. Matsumoto Kalina Hristova Elena B. Pasquale Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
description	Eph receptor tyrosine kinases and their ephrin ligands mediate cell-cell communication. Here, the authors assess the structure and dynamics of the EphA2 intracellular region and uncover complex effects of phosphorylation within the linker region between EphA2 kinase and SAM domains.
format	article
author	Bernhard C. Lechtenberg Marina P. Gehring Taylor P. Light Christopher R. Horne Mike W. Matsumoto Kalina Hristova Elena B. Pasquale
author_facet	Bernhard C. Lechtenberg Marina P. Gehring Taylor P. Light Christopher R. Horne Mike W. Matsumoto Kalina Hristova Elena B. Pasquale
author_sort	Bernhard C. Lechtenberg
title	Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
title_short	Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
title_full	Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
title_fullStr	Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
title_full_unstemmed	Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker
title_sort	regulation of the epha2 receptor intracellular region by phosphomimetic negative charges in the kinase-sam linker
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e61813b18fe47238560b7007035a60e
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Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker

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