A method to find longevity-selected positions in the mammalian proteome.

Evolutionary theory suggests that the force of natural selection decreases with age. To explore the extent to which this prediction directly affects protein structure and function, we used multiple regression to find longevity-selected positions, defined as the columns of a sequence alignment conser...

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Autores principales: Jeremy Semeiks, Nick V Grishin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/4e6cd535603f43648b33404c83b745a7
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