PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions

Abstract Charge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence...

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Autores principales:	Sonia T. Nicolaou, Max Hebditch, Owen J. Jonathan, Chandra S. Verma, Jim Warwicker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e6fab92ba564343bcfe957238eafca2
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spelling	oai:doaj.org-article:4e6fab92ba564343bcfe957238eafca22021-12-02T16:51:03ZPhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions10.1038/s41598-021-88992-02045-2322https://doaj.org/article/4e6fab92ba564343bcfe957238eafca22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88992-0https://doaj.org/toc/2045-2322Abstract Charge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence would assist in the functional interpretation of IDPs and IDRs. PhosIDP is a web tool that shows variation of charge and fold propensity upon phosphorylation. In combination with the displayed location of protein domains, the information provided by the web tool can lead to functional inferences for the consequences of phosphorylation. IDRs are components of many proteins that form biological condensates. It is shown that IDR charge, and its modulation by phosphorylation, is more tightly controlled for proteins that are essential for condensate formation than for those present in condensates but inessential.Sonia T. NicolaouMax HebditchOwen J. JonathanChandra S. VermaJim WarwickerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sonia T. Nicolaou Max Hebditch Owen J. Jonathan Chandra S. Verma Jim Warwicker PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions
description	Abstract Charge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence would assist in the functional interpretation of IDPs and IDRs. PhosIDP is a web tool that shows variation of charge and fold propensity upon phosphorylation. In combination with the displayed location of protein domains, the information provided by the web tool can lead to functional inferences for the consequences of phosphorylation. IDRs are components of many proteins that form biological condensates. It is shown that IDR charge, and its modulation by phosphorylation, is more tightly controlled for proteins that are essential for condensate formation than for those present in condensates but inessential.
format	article
author	Sonia T. Nicolaou Max Hebditch Owen J. Jonathan Chandra S. Verma Jim Warwicker
author_facet	Sonia T. Nicolaou Max Hebditch Owen J. Jonathan Chandra S. Verma Jim Warwicker
author_sort	Sonia T. Nicolaou
title	PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions
title_short	PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions
title_full	PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions
title_fullStr	PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions
title_full_unstemmed	PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions
title_sort	phosidp: a web tool to visualize the location of phosphorylation sites in disordered regions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e6fab92ba564343bcfe957238eafca2
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PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions

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