A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

In fission yeast, Erh1, ortholog of human ERH, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC), which has been implicated in gene silencing. Here, the authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise...

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Autores principales:	Guodong Xie, Tommy V. Vo, Gobi Thillainadesan, Sahana Holla, Beibei Zhang, Yiyang Jiang, Mengqi Lv, Zheng Xu, Chongyuan Wang, Vanivilasini Balachandran, Yunyu Shi, Fudong Li, Shiv I. S. Grewal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e751db81f374d0581b9e726b90ed9a9
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spelling	oai:doaj.org-article:4e751db81f374d0581b9e726b90ed9a92021-12-02T14:38:58ZA conserved dimer interface connects ERH and YTH family proteins to promote gene silencing10.1038/s41467-018-08273-92041-1723https://doaj.org/article/4e751db81f374d0581b9e726b90ed9a92019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08273-9https://doaj.org/toc/2041-1723In fission yeast, Erh1, ortholog of human ERH, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC), which has been implicated in gene silencing. Here, the authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise the role of EMC in facultative heterochromatin assembly and gene silencing.Guodong XieTommy V. VoGobi ThillainadesanSahana HollaBeibei ZhangYiyang JiangMengqi LvZheng XuChongyuan WangVanivilasini BalachandranYunyu ShiFudong LiShiv I. S. GrewalNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guodong Xie Tommy V. Vo Gobi Thillainadesan Sahana Holla Beibei Zhang Yiyang Jiang Mengqi Lv Zheng Xu Chongyuan Wang Vanivilasini Balachandran Yunyu Shi Fudong Li Shiv I. S. Grewal A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
description	In fission yeast, Erh1, ortholog of human ERH, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC), which has been implicated in gene silencing. Here, the authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise the role of EMC in facultative heterochromatin assembly and gene silencing.
format	article
author	Guodong Xie Tommy V. Vo Gobi Thillainadesan Sahana Holla Beibei Zhang Yiyang Jiang Mengqi Lv Zheng Xu Chongyuan Wang Vanivilasini Balachandran Yunyu Shi Fudong Li Shiv I. S. Grewal
author_facet	Guodong Xie Tommy V. Vo Gobi Thillainadesan Sahana Holla Beibei Zhang Yiyang Jiang Mengqi Lv Zheng Xu Chongyuan Wang Vanivilasini Balachandran Yunyu Shi Fudong Li Shiv I. S. Grewal
author_sort	Guodong Xie
title	A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
title_short	A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
title_full	A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
title_fullStr	A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
title_full_unstemmed	A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
title_sort	conserved dimer interface connects erh and yth family proteins to promote gene silencing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4e751db81f374d0581b9e726b90ed9a9
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A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

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