A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

In fission yeast, Erh1, ortholog of human ERH, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC), which has been implicated in gene silencing. Here, the authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise...

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Autores principales: Guodong Xie, Tommy V. Vo, Gobi Thillainadesan, Sahana Holla, Beibei Zhang, Yiyang Jiang, Mengqi Lv, Zheng Xu, Chongyuan Wang, Vanivilasini Balachandran, Yunyu Shi, Fudong Li, Shiv I. S. Grewal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/4e751db81f374d0581b9e726b90ed9a9
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