An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause

An outbreak investigation was initiated in September 2019, following a notification to the Norwegian Food Safety Authority (NFSA) of an unusually high number of dogs with acute haemorrhagic diarrhoea (AHD) in Oslo. Diagnostic testing by reporting veterinarians had not detected a cause. The official...

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Autores principales:	Hannah Joan Jørgensen, Mette Valheim, Camilla Sekse, Bjarne Asbjørn Bergsjø, Helene Wisløff, Simen Foyn Nørstebø, Ellen Skancke, Karin Lagesen, Anita Haug Haaland, Sabrina Rodriguez-Campos, Siri Kulberg Sjurseth, Merete Hofshagen, Jorun Jarp, Ole-Herman Tronerud, Gro Skøien Johannessen, Monica Heggelund, Sasja Rygg, Ellen Christensen, Mette Boye, Britt Gjerset, Morten Sandvik, Eiril Moen Soltvedt, Cecilia Wolff
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	canine diarrhoea whole genome sequencing haemorrhagic gastroenteritis Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/4e7a4bc5d0b7403894b94ce45a94e123
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spelling	oai:doaj.org-article:4e7a4bc5d0b7403894b94ce45a94e1232021-11-25T16:18:54ZAn Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause10.3390/ani111132012076-2615https://doaj.org/article/4e7a4bc5d0b7403894b94ce45a94e1232021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3201https://doaj.org/toc/2076-2615An outbreak investigation was initiated in September 2019, following a notification to the Norwegian Food Safety Authority (NFSA) of an unusually high number of dogs with acute haemorrhagic diarrhoea (AHD) in Oslo. Diagnostic testing by reporting veterinarians had not detected a cause. The official investigation sought to identify a possible common cause, the extent of the outbreak and prevent spread. Epidemiological data were collected through a survey to veterinarians and interviews with dog owners. Diagnostic investigations included necropsies and microbiological, parasitological and toxicological analysis of faecal samples and food. In total, 511 dogs with acute haemorrhagic diarrhoea were registered between 1 August and 1 October. Results indicated a common point source for affected dogs, but were inconclusive with regard to common exposures. A notable finding was that 134 of 325 faecal samples (41%) cultured positive for <i>Providencia alcalifaciens</i>. Whole genome sequencing (WGS) of 75 <i>P. alcalifaciens</i> isolates from 73 dogs revealed that strains from 51 dogs belonged to the same WGS clone. Findings point to <i>P. alcalifaciens</i> as implicated in the outbreak, but investigations are needed to reveal the pathogenic potential of <i>P. alcalifaciens</i> in dogs and its epidemiology.Hannah Joan JørgensenMette ValheimCamilla SekseBjarne Asbjørn BergsjøHelene WisløffSimen Foyn NørstebøEllen SkanckeKarin LagesenAnita Haug HaalandSabrina Rodriguez-CamposSiri Kulberg SjursethMerete HofshagenJorun JarpOle-Herman TronerudGro Skøien JohannessenMonica HeggelundSasja RyggEllen ChristensenMette BoyeBritt GjersetMorten SandvikEiril Moen SoltvedtCecilia WolffMDPI AGarticlecaninediarrhoeawhole genome sequencinghaemorrhagic gastroenteritisVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3201, p 3201 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	canine diarrhoea whole genome sequencing haemorrhagic gastroenteritis Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	canine diarrhoea whole genome sequencing haemorrhagic gastroenteritis Veterinary medicine SF600-1100 Zoology QL1-991 Hannah Joan Jørgensen Mette Valheim Camilla Sekse Bjarne Asbjørn Bergsjø Helene Wisløff Simen Foyn Nørstebø Ellen Skancke Karin Lagesen Anita Haug Haaland Sabrina Rodriguez-Campos Siri Kulberg Sjurseth Merete Hofshagen Jorun Jarp Ole-Herman Tronerud Gro Skøien Johannessen Monica Heggelund Sasja Rygg Ellen Christensen Mette Boye Britt Gjerset Morten Sandvik Eiril Moen Soltvedt Cecilia Wolff An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause
description	An outbreak investigation was initiated in September 2019, following a notification to the Norwegian Food Safety Authority (NFSA) of an unusually high number of dogs with acute haemorrhagic diarrhoea (AHD) in Oslo. Diagnostic testing by reporting veterinarians had not detected a cause. The official investigation sought to identify a possible common cause, the extent of the outbreak and prevent spread. Epidemiological data were collected through a survey to veterinarians and interviews with dog owners. Diagnostic investigations included necropsies and microbiological, parasitological and toxicological analysis of faecal samples and food. In total, 511 dogs with acute haemorrhagic diarrhoea were registered between 1 August and 1 October. Results indicated a common point source for affected dogs, but were inconclusive with regard to common exposures. A notable finding was that 134 of 325 faecal samples (41%) cultured positive for <i>Providencia alcalifaciens</i>. Whole genome sequencing (WGS) of 75 <i>P. alcalifaciens</i> isolates from 73 dogs revealed that strains from 51 dogs belonged to the same WGS clone. Findings point to <i>P. alcalifaciens</i> as implicated in the outbreak, but investigations are needed to reveal the pathogenic potential of <i>P. alcalifaciens</i> in dogs and its epidemiology.
format	article
author	Hannah Joan Jørgensen Mette Valheim Camilla Sekse Bjarne Asbjørn Bergsjø Helene Wisløff Simen Foyn Nørstebø Ellen Skancke Karin Lagesen Anita Haug Haaland Sabrina Rodriguez-Campos Siri Kulberg Sjurseth Merete Hofshagen Jorun Jarp Ole-Herman Tronerud Gro Skøien Johannessen Monica Heggelund Sasja Rygg Ellen Christensen Mette Boye Britt Gjerset Morten Sandvik Eiril Moen Soltvedt Cecilia Wolff
author_facet	Hannah Joan Jørgensen Mette Valheim Camilla Sekse Bjarne Asbjørn Bergsjø Helene Wisløff Simen Foyn Nørstebø Ellen Skancke Karin Lagesen Anita Haug Haaland Sabrina Rodriguez-Campos Siri Kulberg Sjurseth Merete Hofshagen Jorun Jarp Ole-Herman Tronerud Gro Skøien Johannessen Monica Heggelund Sasja Rygg Ellen Christensen Mette Boye Britt Gjerset Morten Sandvik Eiril Moen Soltvedt Cecilia Wolff
author_sort	Hannah Joan Jørgensen
title	An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause
title_short	An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause
title_full	An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause
title_fullStr	An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause
title_full_unstemmed	An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause
title_sort	official outbreak investigation of acute haemorrhagic diarrhoea in dogs in norway points to <i>providencia alcalifaciens</i> as a likely cause
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4e7a4bc5d0b7403894b94ce45a94e123
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An Official Outbreak Investigation of Acute Haemorrhagic Diarrhoea in Dogs in Norway Points to <i>Providencia alcalifaciens</i> as a Likely Cause

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