Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor

β1-adrenergic receptors are expressed in cardiac tissue and stimulated by the sympathetic nervous system. Here, the authors use NMR spectroscopy to unravel the conformational diversity upon β1-adrenergic receptor activation and provide structural insights into partial agonism and basal activity.

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Autores principales:	Andras S. Solt, Mark J. Bostock, Binesh Shrestha, Prashant Kumar, Tony Warne, Christopher G. Tate, Daniel Nietlispach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e7fd3c6652e45599736267dcb9722e4
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spelling	oai:doaj.org-article:4e7fd3c6652e45599736267dcb9722e42021-12-02T14:40:59ZInsight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor10.1038/s41467-017-02008-y2041-1723https://doaj.org/article/4e7fd3c6652e45599736267dcb9722e42017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02008-yhttps://doaj.org/toc/2041-1723β1-adrenergic receptors are expressed in cardiac tissue and stimulated by the sympathetic nervous system. Here, the authors use NMR spectroscopy to unravel the conformational diversity upon β1-adrenergic receptor activation and provide structural insights into partial agonism and basal activity.Andras S. SoltMark J. BostockBinesh ShresthaPrashant KumarTony WarneChristopher G. TateDaniel NietlispachNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andras S. Solt Mark J. Bostock Binesh Shrestha Prashant Kumar Tony Warne Christopher G. Tate Daniel Nietlispach Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
description	β1-adrenergic receptors are expressed in cardiac tissue and stimulated by the sympathetic nervous system. Here, the authors use NMR spectroscopy to unravel the conformational diversity upon β1-adrenergic receptor activation and provide structural insights into partial agonism and basal activity.
format	article
author	Andras S. Solt Mark J. Bostock Binesh Shrestha Prashant Kumar Tony Warne Christopher G. Tate Daniel Nietlispach
author_facet	Andras S. Solt Mark J. Bostock Binesh Shrestha Prashant Kumar Tony Warne Christopher G. Tate Daniel Nietlispach
author_sort	Andras S. Solt
title	Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
title_short	Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
title_full	Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
title_fullStr	Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
title_full_unstemmed	Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
title_sort	insight into partial agonism by observing multiple equilibria for ligand-bound and gs-mimetic nanobody-bound β1-adrenergic receptor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4e7fd3c6652e45599736267dcb9722e4
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Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor

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