Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis

Abstract Turmeric has been used as a medicinal herb for thousands of years for treatment of various disorders. Although curcumin is the most studied active constituents of turmeric, accumulating evidence suggests that other components of turmeric have additional anti-inflammatory and anti-tumorigeni...

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Autores principales:	Shusuke Toden, Arianne L. Theiss, Xuan Wang, Ajay Goel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e80c3977197493692b4e4d2eddef671
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spelling	oai:doaj.org-article:4e80c3977197493692b4e4d2eddef6712021-12-02T15:05:25ZEssential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis10.1038/s41598-017-00812-62045-2322https://doaj.org/article/4e80c3977197493692b4e4d2eddef6712017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00812-6https://doaj.org/toc/2045-2322Abstract Turmeric has been used as a medicinal herb for thousands of years for treatment of various disorders. Although curcumin is the most studied active constituents of turmeric, accumulating evidence suggests that other components of turmeric have additional anti-inflammatory and anti-tumorigenic properties. Herein, we investigated anti-inflammatory efficacy and associated gene expression alterations of a specific, curcumin preparation containing essential turmeric oils (ETO-curcumin) in comparison to standard curcumin at three specific doses (0, 5, 25 or 50 mg/kg), in an animal model of dextran sodium sulfate (DSS)-induced colitis. The present study showed that both ETO and standard curcumin treatments provided protection against DSS-induced inflammation. However, ETO-curcumin improved disease activity index (DAI) dose-dependently, while the anti-inflammatory efficacy of standard curcumin remained constant, suggesting that ETO-curcumin may provide superior anti-inflammatory efficacy compared to standard curcumin. Gene expression analysis revealed that anti-inflammatory cytokines including IL-10 and IL-11 as well as FOXP3 were upregulated in the colon by ETO-curcumin. Collectively, these findings suggest that the combined treatment of curcumin and essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone, highlighting the anti-inflammatory potential of turmeric.Shusuke TodenArianne L. TheissXuan WangAjay GoelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shusuke Toden Arianne L. Theiss Xuan Wang Ajay Goel Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
description	Abstract Turmeric has been used as a medicinal herb for thousands of years for treatment of various disorders. Although curcumin is the most studied active constituents of turmeric, accumulating evidence suggests that other components of turmeric have additional anti-inflammatory and anti-tumorigenic properties. Herein, we investigated anti-inflammatory efficacy and associated gene expression alterations of a specific, curcumin preparation containing essential turmeric oils (ETO-curcumin) in comparison to standard curcumin at three specific doses (0, 5, 25 or 50 mg/kg), in an animal model of dextran sodium sulfate (DSS)-induced colitis. The present study showed that both ETO and standard curcumin treatments provided protection against DSS-induced inflammation. However, ETO-curcumin improved disease activity index (DAI) dose-dependently, while the anti-inflammatory efficacy of standard curcumin remained constant, suggesting that ETO-curcumin may provide superior anti-inflammatory efficacy compared to standard curcumin. Gene expression analysis revealed that anti-inflammatory cytokines including IL-10 and IL-11 as well as FOXP3 were upregulated in the colon by ETO-curcumin. Collectively, these findings suggest that the combined treatment of curcumin and essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone, highlighting the anti-inflammatory potential of turmeric.
format	article
author	Shusuke Toden Arianne L. Theiss Xuan Wang Ajay Goel
author_facet	Shusuke Toden Arianne L. Theiss Xuan Wang Ajay Goel
author_sort	Shusuke Toden
title	Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
title_short	Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
title_full	Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
title_fullStr	Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
title_full_unstemmed	Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
title_sort	essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4e80c3977197493692b4e4d2eddef671
work_keys_str_mv	AT shusuketoden essentialturmericoilsenhanceantiinflammatoryefficacyofcurcuminindextransulfatesodiuminducedcolitis AT arianneltheiss essentialturmericoilsenhanceantiinflammatoryefficacyofcurcuminindextransulfatesodiuminducedcolitis AT xuanwang essentialturmericoilsenhanceantiinflammatoryefficacyofcurcuminindextransulfatesodiuminducedcolitis AT ajaygoel essentialturmericoilsenhanceantiinflammatoryefficacyofcurcuminindextransulfatesodiuminducedcolitis
_version_	1718388827976892416

Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis

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