Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy

Abstract Despite encouraging results reported with regards to Platelet-rich plasma (PRP) application in osteoarthritis (OA) knee, still critical issues like conclusive structural evidence of its efficacy, standard dose and good manual method of preparation to obtain high yield remains unanswered. Pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Himanshu Bansal, Jerry Leon, Jeremy L. Pont, David A. Wilson, Anupama Bansal, Diwaker Agarwal, Iustin Preoteasa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e841b9e14ad4edaa44e2195129ece58
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4e841b9e14ad4edaa44e2195129ece58
record_format	dspace
spelling	oai:doaj.org-article:4e841b9e14ad4edaa44e2195129ece582021-12-02T14:03:58ZPlatelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy10.1038/s41598-021-83025-22045-2322https://doaj.org/article/4e841b9e14ad4edaa44e2195129ece582021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83025-2https://doaj.org/toc/2045-2322Abstract Despite encouraging results reported with regards to Platelet-rich plasma (PRP) application in osteoarthritis (OA) knee, still critical issues like conclusive structural evidence of its efficacy, standard dose and good manual method of preparation to obtain high yield remains unanswered. Present study is an attempt to optimise the dose and concentration of therapeutic PRP and its correlation with structural, physiologic efficacy with a new manual method of PRP preparation. A total of one hundred and fifty patients were randomized to receive either PRP (10 billion platelets) or hyaluronic acid (HA; 4 ml; 75 patients in each group) and followed up till 1 year. An addition of filtration step with 1 µm filter in manual PRP processing improved platelet recovery upto 90%. Significant improvements in WOMAC (51.94 ± 7.35 vs. 57.33 ± 8.92; P < 0.001), IKDC scores (62.8 ± 6.24 vs 52.7 ± 6.39; P < 0.001), 6-min pain free walking distance (+ 120 vs. + 4; P < 0.001) persisted in PRP compared to HA group at 1 year. Significant decline IL-6 and TNF-α levels observed in PRP group (P < 0.05) compared to HA at 1 month. Study demonstrated that an absolute count of 10 billion platelets is crucial in a PRP formulation to have long sustained chondroprotective effect upto one year in moderate knee OA.Himanshu BansalJerry LeonJeremy L. PontDavid A. WilsonAnupama BansalDiwaker AgarwalIustin PreoteasaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Himanshu Bansal Jerry Leon Jeremy L. Pont David A. Wilson Anupama Bansal Diwaker Agarwal Iustin Preoteasa Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy
description	Abstract Despite encouraging results reported with regards to Platelet-rich plasma (PRP) application in osteoarthritis (OA) knee, still critical issues like conclusive structural evidence of its efficacy, standard dose and good manual method of preparation to obtain high yield remains unanswered. Present study is an attempt to optimise the dose and concentration of therapeutic PRP and its correlation with structural, physiologic efficacy with a new manual method of PRP preparation. A total of one hundred and fifty patients were randomized to receive either PRP (10 billion platelets) or hyaluronic acid (HA; 4 ml; 75 patients in each group) and followed up till 1 year. An addition of filtration step with 1 µm filter in manual PRP processing improved platelet recovery upto 90%. Significant improvements in WOMAC (51.94 ± 7.35 vs. 57.33 ± 8.92; P < 0.001), IKDC scores (62.8 ± 6.24 vs 52.7 ± 6.39; P < 0.001), 6-min pain free walking distance (+ 120 vs. + 4; P < 0.001) persisted in PRP compared to HA group at 1 year. Significant decline IL-6 and TNF-α levels observed in PRP group (P < 0.05) compared to HA at 1 month. Study demonstrated that an absolute count of 10 billion platelets is crucial in a PRP formulation to have long sustained chondroprotective effect upto one year in moderate knee OA.
format	article
author	Himanshu Bansal Jerry Leon Jeremy L. Pont David A. Wilson Anupama Bansal Diwaker Agarwal Iustin Preoteasa
author_facet	Himanshu Bansal Jerry Leon Jeremy L. Pont David A. Wilson Anupama Bansal Diwaker Agarwal Iustin Preoteasa
author_sort	Himanshu Bansal
title	Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy
title_short	Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy
title_full	Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy
title_fullStr	Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy
title_full_unstemmed	Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy
title_sort	platelet-rich plasma (prp) in osteoarthritis (oa) knee: correct dose critical for long term clinical efficacy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4e841b9e14ad4edaa44e2195129ece58
work_keys_str_mv	AT himanshubansal plateletrichplasmaprpinosteoarthritisoakneecorrectdosecriticalforlongtermclinicalefficacy AT jerryleon plateletrichplasmaprpinosteoarthritisoakneecorrectdosecriticalforlongtermclinicalefficacy AT jeremylpont plateletrichplasmaprpinosteoarthritisoakneecorrectdosecriticalforlongtermclinicalefficacy AT davidawilson plateletrichplasmaprpinosteoarthritisoakneecorrectdosecriticalforlongtermclinicalefficacy AT anupamabansal plateletrichplasmaprpinosteoarthritisoakneecorrectdosecriticalforlongtermclinicalefficacy AT diwakeragarwal plateletrichplasmaprpinosteoarthritisoakneecorrectdosecriticalforlongtermclinicalefficacy AT iustinpreoteasa plateletrichplasmaprpinosteoarthritisoakneecorrectdosecriticalforlongtermclinicalefficacy
_version_	1718392018348015616

Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy

Ejemplares similares