Integrated molecular landscape of Parkinson’s disease

Molecular interactions: the importance of fats Lipids and lipoproteins play a central role in four key biological processes underlying Parkinson’s disease (PD). Using bioinformatics and other extensive analyses of previously published data, Geert Poelmans, Cornelius Klemann and colleagues in The Net...

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Autores principales:	C. J. H. M. Klemann, G. J. M. Martens, M. Sharma, M. B. Martens, O. Isacson, T. Gasser, J. E. Visser, G. Poelmans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4e860d8b3bd7468199c2d2e11594e038
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spelling	oai:doaj.org-article:4e860d8b3bd7468199c2d2e11594e0382021-12-02T12:33:37ZIntegrated molecular landscape of Parkinson’s disease10.1038/s41531-017-0015-32373-8057https://doaj.org/article/4e860d8b3bd7468199c2d2e11594e0382017-04-01T00:00:00Zhttps://doi.org/10.1038/s41531-017-0015-3https://doaj.org/toc/2373-8057Molecular interactions: the importance of fats Lipids and lipoproteins play a central role in four key biological processes underlying Parkinson’s disease (PD). Using bioinformatics and other extensive analyses of previously published data, Geert Poelmans, Cornelius Klemann and colleagues in The Netherlands, Germany and the USA have mapped the interactions of proteins that are encoded by genes associated with both familial and sporadic forms of PD. They identify the oxidative stress response, lysosomal function, endoplasmic reticulum stress response and immune response activation as the main mechanisms leading to the death of dopaminergic neurons. Lipid signaling is implicated in all four of these processes and the authors find a link between the levels of particular lipids and lipoproteins and the risk of PD. These findings suggest that compounds that regulate lipid or lipoprotein levels offer a potential new treatment strategy for PD.C. J. H. M. KlemannG. J. M. MartensM. SharmaM. B. MartensO. IsacsonT. GasserJ. E. VisserG. PoelmansNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 3, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 C. J. H. M. Klemann G. J. M. Martens M. Sharma M. B. Martens O. Isacson T. Gasser J. E. Visser G. Poelmans Integrated molecular landscape of Parkinson’s disease
description	Molecular interactions: the importance of fats Lipids and lipoproteins play a central role in four key biological processes underlying Parkinson’s disease (PD). Using bioinformatics and other extensive analyses of previously published data, Geert Poelmans, Cornelius Klemann and colleagues in The Netherlands, Germany and the USA have mapped the interactions of proteins that are encoded by genes associated with both familial and sporadic forms of PD. They identify the oxidative stress response, lysosomal function, endoplasmic reticulum stress response and immune response activation as the main mechanisms leading to the death of dopaminergic neurons. Lipid signaling is implicated in all four of these processes and the authors find a link between the levels of particular lipids and lipoproteins and the risk of PD. These findings suggest that compounds that regulate lipid or lipoprotein levels offer a potential new treatment strategy for PD.
format	article
author	C. J. H. M. Klemann G. J. M. Martens M. Sharma M. B. Martens O. Isacson T. Gasser J. E. Visser G. Poelmans
author_facet	C. J. H. M. Klemann G. J. M. Martens M. Sharma M. B. Martens O. Isacson T. Gasser J. E. Visser G. Poelmans
author_sort	C. J. H. M. Klemann
title	Integrated molecular landscape of Parkinson’s disease
title_short	Integrated molecular landscape of Parkinson’s disease
title_full	Integrated molecular landscape of Parkinson’s disease
title_fullStr	Integrated molecular landscape of Parkinson’s disease
title_full_unstemmed	Integrated molecular landscape of Parkinson’s disease
title_sort	integrated molecular landscape of parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4e860d8b3bd7468199c2d2e11594e038
work_keys_str_mv	AT cjhmklemann integratedmolecularlandscapeofparkinsonsdisease AT gjmmartens integratedmolecularlandscapeofparkinsonsdisease AT msharma integratedmolecularlandscapeofparkinsonsdisease AT mbmartens integratedmolecularlandscapeofparkinsonsdisease AT oisacson integratedmolecularlandscapeofparkinsonsdisease AT tgasser integratedmolecularlandscapeofparkinsonsdisease AT jevisser integratedmolecularlandscapeofparkinsonsdisease AT gpoelmans integratedmolecularlandscapeofparkinsonsdisease
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Integrated molecular landscape of Parkinson’s disease

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