Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.

Organophosphorus pesticides (OPs) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Over the past years evidence is mounting that these compounds affect many other processes. Little is kn...

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Autores principales:	Ana Viñuela, L Basten Snoek, Joost A G Riksen, Jan E Kammenga
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e875ce57bad4d11b3ec0acd9dca444e
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spelling	oai:doaj.org-article:4e875ce57bad4d11b3ec0acd9dca444e2021-11-18T06:36:03ZGenome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.1932-620310.1371/journal.pone.0012145https://doaj.org/article/4e875ce57bad4d11b3ec0acd9dca444e2010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808445/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Organophosphorus pesticides (OPs) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Over the past years evidence is mounting that these compounds affect many other processes. Little is known, however, about gene expression responses against OPs in the nematode Caenorhabditis elegans. This is surprising because C. elegans is extensively used as a model species in toxicity studies. To address this question we performed a microarray study in C. elegans which was exposed for 72 hrs to two widely used Ops, chlorpyrifos and diazinon, and a low dose mixture of these two compounds. Our analysis revealed transcriptional responses related to detoxification, stress, innate immunity, and transport and metabolism of lipids in all treatments. We found that for both compounds as well as in the mixture, these processes were regulated by different gene transcripts. Our results illustrate intense, and unexpected crosstalk between gene pathways in response to chlorpyrifos and diazinon in C. elegans.Ana ViñuelaL Basten SnoekJoost A G RiksenJan E KammengaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e12145 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.
description	Organophosphorus pesticides (OPs) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Over the past years evidence is mounting that these compounds affect many other processes. Little is known, however, about gene expression responses against OPs in the nematode Caenorhabditis elegans. This is surprising because C. elegans is extensively used as a model species in toxicity studies. To address this question we performed a microarray study in C. elegans which was exposed for 72 hrs to two widely used Ops, chlorpyrifos and diazinon, and a low dose mixture of these two compounds. Our analysis revealed transcriptional responses related to detoxification, stress, innate immunity, and transport and metabolism of lipids in all treatments. We found that for both compounds as well as in the mixture, these processes were regulated by different gene transcripts. Our results illustrate intense, and unexpected crosstalk between gene pathways in response to chlorpyrifos and diazinon in C. elegans.
format	article
author	Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga
author_facet	Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga
author_sort	Ana Viñuela
title	Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.
title_short	Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.
title_full	Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.
title_fullStr	Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.
title_full_unstemmed	Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.
title_sort	genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in c. elegans.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/4e875ce57bad4d11b3ec0acd9dca444e
work_keys_str_mv	AT anavinuela genomewidegeneexpressionanalysisinresponsetoorganophosphoruspesticidechlorpyrifosanddiazinonincelegans AT lbastensnoek genomewidegeneexpressionanalysisinresponsetoorganophosphoruspesticidechlorpyrifosanddiazinonincelegans AT joostagriksen genomewidegeneexpressionanalysisinresponsetoorganophosphoruspesticidechlorpyrifosanddiazinonincelegans AT janekammenga genomewidegeneexpressionanalysisinresponsetoorganophosphoruspesticidechlorpyrifosanddiazinonincelegans
_version_	1718424412937519104

Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.

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