Short Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health

Botany-derived antimicrobial peptides (BAMPs), a class of small, cysteine-rich peptides produced in plants, are an important component of the plant immune system. Both in vivo and in vitro experiments have demonstrated their powerful antimicrobial activity. Besides in plants, BAMPs have cross-kingdo...

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Autores principales:	Xiumei Luo, Wenxian Wu, Li Feng, Haim Treves, Maozhi Ren
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	botany-derived antimicrobial peptides mechanism of action molecular targets disease prevention and control health security Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4e8bbca981294d88af3be61173be99a4
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spelling	oai:doaj.org-article:4e8bbca981294d88af3be61173be99a42021-11-11T16:50:15ZShort Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health10.3390/ijms2221113631422-00671661-6596https://doaj.org/article/4e8bbca981294d88af3be61173be99a42021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11363https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Botany-derived antimicrobial peptides (BAMPs), a class of small, cysteine-rich peptides produced in plants, are an important component of the plant immune system. Both in vivo and in vitro experiments have demonstrated their powerful antimicrobial activity. Besides in plants, BAMPs have cross-kingdom applications in human health, with toxic and/or inhibitory effects against a variety of tumor cells and viruses. With their diverse molecular structures, broad-spectrum antimicrobial activity, multiple mechanisms of action, and low cytotoxicity, BAMPs provide ideal backbones for drug design, and are potential candidates for plant protection and disease treatment. Lots of original research has elucidated the properties and antimicrobial mechanisms of BAMPs, and characterized their surface receptors and in vivo targets in pathogens. In this paper, we review and introduce five kinds of representative BAMPs belonging to the pathogenesis-related protein family, dissect their antifungal, antiviral, and anticancer mechanisms, and forecast their prospects in agriculture and global human health. Through the deeper understanding of BAMPs, we provide novel insights for their applications in broad-spectrum and durable plant disease prevention and control, and an outlook on the use of BAMPs in anticancer and antiviral drug design.Xiumei LuoWenxian WuLi FengHaim TrevesMaozhi RenMDPI AGarticlebotany-derived antimicrobial peptidesmechanism of actionmolecular targetsdisease prevention and controlhealth securityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11363, p 11363 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	botany-derived antimicrobial peptides mechanism of action molecular targets disease prevention and control health security Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	botany-derived antimicrobial peptides mechanism of action molecular targets disease prevention and control health security Biology (General) QH301-705.5 Chemistry QD1-999 Xiumei Luo Wenxian Wu Li Feng Haim Treves Maozhi Ren Short Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health
description	Botany-derived antimicrobial peptides (BAMPs), a class of small, cysteine-rich peptides produced in plants, are an important component of the plant immune system. Both in vivo and in vitro experiments have demonstrated their powerful antimicrobial activity. Besides in plants, BAMPs have cross-kingdom applications in human health, with toxic and/or inhibitory effects against a variety of tumor cells and viruses. With their diverse molecular structures, broad-spectrum antimicrobial activity, multiple mechanisms of action, and low cytotoxicity, BAMPs provide ideal backbones for drug design, and are potential candidates for plant protection and disease treatment. Lots of original research has elucidated the properties and antimicrobial mechanisms of BAMPs, and characterized their surface receptors and in vivo targets in pathogens. In this paper, we review and introduce five kinds of representative BAMPs belonging to the pathogenesis-related protein family, dissect their antifungal, antiviral, and anticancer mechanisms, and forecast their prospects in agriculture and global human health. Through the deeper understanding of BAMPs, we provide novel insights for their applications in broad-spectrum and durable plant disease prevention and control, and an outlook on the use of BAMPs in anticancer and antiviral drug design.
format	article
author	Xiumei Luo Wenxian Wu Li Feng Haim Treves Maozhi Ren
author_facet	Xiumei Luo Wenxian Wu Li Feng Haim Treves Maozhi Ren
author_sort	Xiumei Luo
title	Short Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health
title_short	Short Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health
title_full	Short Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health
title_fullStr	Short Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health
title_full_unstemmed	Short Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health
title_sort	short peptides make a big difference: the role of botany-derived amps in disease control and protection of human health
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4e8bbca981294d88af3be61173be99a4
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Short Peptides Make a Big Difference: The Role of Botany-Derived AMPs in Disease Control and Protection of Human Health

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