Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility
Abstract The structural morphology of coronary stents (e.g. stent expansion, lumen scaffolding, strut apposition, tissue protrusion, side branch jailing, strut fracture), and the local hemodynamic environment after stent deployment are key determinants of procedural success and subsequent clinical o...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/4e8e411772d242da95522174659fd071 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:4e8e411772d242da95522174659fd071 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:4e8e411772d242da95522174659fd0712021-12-02T15:03:07ZThree dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility10.1038/s41598-021-91458-y2045-2322https://doaj.org/article/4e8e411772d242da95522174659fd0712021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91458-yhttps://doaj.org/toc/2045-2322Abstract The structural morphology of coronary stents (e.g. stent expansion, lumen scaffolding, strut apposition, tissue protrusion, side branch jailing, strut fracture), and the local hemodynamic environment after stent deployment are key determinants of procedural success and subsequent clinical outcomes. High-resolution intracoronary imaging has the potential to enable the geometrically accurate three-dimensional (3D) reconstruction of coronary stents. The aim of this work was to present a novel algorithm for 3D stent reconstruction of coronary artery stents based on optical coherence tomography (OCT) and angiography, and test experimentally its accuracy, reproducibility, clinical feasibility, and ability to perform computational fluid dynamics (CFD) studies. Our method has the following steps: 3D lumen reconstruction based on OCT and angiography, stent strut segmentation in OCT images, packaging, rotation and straightening of the segmented struts, planar unrolling of the segmented struts, planar stent wireframe reconstruction, rolling back of the planar stent wireframe to the 3D reconstructed lumen, and final stent volume reconstruction. We tested the accuracy and reproducibility of our method in stented patient-specific silicone models using micro-computed tomography (μCT) and stereoscopy as references. The clinical feasibility and CFD studies were performed in clinically stented coronary bifurcations. The experimental and clinical studies showed that our algorithm (1) can reproduce the complex spatial stent configuration with high precision and reproducibility, (2) is feasible in 3D reconstructing stents deployed in bifurcations, and (3) enables CFD studies to assess the local hemodynamic environment within the stent. Notably, the high accuracy of our algorithm was consistent across different stent designs and diameters. Our method coupled with patient-specific CFD studies can lay the ground for optimization of stenting procedures, patient-specific computational stenting simulations, and research and development of new stent scaffolds and stenting techniques.Wei WuBehram KhanMohammadali SharzeheeShijia ZhaoSaurabhi SamantYusuke WatanabeYoshinobu MurasatoTimothy MickleyAndrew BicekRichard BlissThomas ValenzuelaPaul A. IaizzoJanaki MakadiaAnastasios PanagopoulosFrancesco BurzottaHabib SamadyEmmanouil S. BrilakisGeorge D. DangasYves LouvardGoran StankovicGabriele DubiniFrancesco MigliavaccaGhassan S. KassabElazer R. EdelmanClaudio ChiastraYiannis S. ChatzizisisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Wei Wu Behram Khan Mohammadali Sharzehee Shijia Zhao Saurabhi Samant Yusuke Watanabe Yoshinobu Murasato Timothy Mickley Andrew Bicek Richard Bliss Thomas Valenzuela Paul A. Iaizzo Janaki Makadia Anastasios Panagopoulos Francesco Burzotta Habib Samady Emmanouil S. Brilakis George D. Dangas Yves Louvard Goran Stankovic Gabriele Dubini Francesco Migliavacca Ghassan S. Kassab Elazer R. Edelman Claudio Chiastra Yiannis S. Chatzizisis Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility |
| description |
Abstract The structural morphology of coronary stents (e.g. stent expansion, lumen scaffolding, strut apposition, tissue protrusion, side branch jailing, strut fracture), and the local hemodynamic environment after stent deployment are key determinants of procedural success and subsequent clinical outcomes. High-resolution intracoronary imaging has the potential to enable the geometrically accurate three-dimensional (3D) reconstruction of coronary stents. The aim of this work was to present a novel algorithm for 3D stent reconstruction of coronary artery stents based on optical coherence tomography (OCT) and angiography, and test experimentally its accuracy, reproducibility, clinical feasibility, and ability to perform computational fluid dynamics (CFD) studies. Our method has the following steps: 3D lumen reconstruction based on OCT and angiography, stent strut segmentation in OCT images, packaging, rotation and straightening of the segmented struts, planar unrolling of the segmented struts, planar stent wireframe reconstruction, rolling back of the planar stent wireframe to the 3D reconstructed lumen, and final stent volume reconstruction. We tested the accuracy and reproducibility of our method in stented patient-specific silicone models using micro-computed tomography (μCT) and stereoscopy as references. The clinical feasibility and CFD studies were performed in clinically stented coronary bifurcations. The experimental and clinical studies showed that our algorithm (1) can reproduce the complex spatial stent configuration with high precision and reproducibility, (2) is feasible in 3D reconstructing stents deployed in bifurcations, and (3) enables CFD studies to assess the local hemodynamic environment within the stent. Notably, the high accuracy of our algorithm was consistent across different stent designs and diameters. Our method coupled with patient-specific CFD studies can lay the ground for optimization of stenting procedures, patient-specific computational stenting simulations, and research and development of new stent scaffolds and stenting techniques. |
| format |
article |
| author |
Wei Wu Behram Khan Mohammadali Sharzehee Shijia Zhao Saurabhi Samant Yusuke Watanabe Yoshinobu Murasato Timothy Mickley Andrew Bicek Richard Bliss Thomas Valenzuela Paul A. Iaizzo Janaki Makadia Anastasios Panagopoulos Francesco Burzotta Habib Samady Emmanouil S. Brilakis George D. Dangas Yves Louvard Goran Stankovic Gabriele Dubini Francesco Migliavacca Ghassan S. Kassab Elazer R. Edelman Claudio Chiastra Yiannis S. Chatzizisis |
| author_facet |
Wei Wu Behram Khan Mohammadali Sharzehee Shijia Zhao Saurabhi Samant Yusuke Watanabe Yoshinobu Murasato Timothy Mickley Andrew Bicek Richard Bliss Thomas Valenzuela Paul A. Iaizzo Janaki Makadia Anastasios Panagopoulos Francesco Burzotta Habib Samady Emmanouil S. Brilakis George D. Dangas Yves Louvard Goran Stankovic Gabriele Dubini Francesco Migliavacca Ghassan S. Kassab Elazer R. Edelman Claudio Chiastra Yiannis S. Chatzizisis |
| author_sort |
Wei Wu |
| title |
Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility |
| title_short |
Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility |
| title_full |
Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility |
| title_fullStr |
Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility |
| title_full_unstemmed |
Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility |
| title_sort |
three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4e8e411772d242da95522174659fd071 |
| work_keys_str_mv |
AT weiwu threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT behramkhan threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT mohammadalisharzehee threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT shijiazhao threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT saurabhisamant threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT yusukewatanabe threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT yoshinobumurasato threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT timothymickley threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT andrewbicek threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT richardbliss threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT thomasvalenzuela threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT paulaiaizzo threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT janakimakadia threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT anastasiospanagopoulos threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT francescoburzotta threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT habibsamady threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT emmanouilsbrilakis threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT georgeddangas threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT yveslouvard threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT goranstankovic threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT gabrieledubini threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT francescomigliavacca threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT ghassanskassab threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT elazerredelman threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT claudiochiastra threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility AT yiannisschatzizisis threedimensionalreconstructionofcoronaryarterystentsfromopticalcoherencetomographyexperimentalvalidationandclinicalfeasibility |
| _version_ |
1718389075515277312 |