Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

The amidotransferase MurT/GatD complex catalyzes peptidoglycan precursor amidation in some Gram-positive bacteria. Here the authors present the crystal structure of the Streptococcus pneumoniae MurT/GatD complex and provide mechanistic insights, which are of interest for drug development.

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Autores principales:	Cécile Morlot, Daniel Straume, Katharina Peters, Olav A. Hegnar, Nolwenn Simon, Anne-Marie Villard, Carlos Contreras-Martel, Francisco Leisico, Eefjan Breukink, Christine Gravier-Pelletier, Laurent Le Corre, Waldemar Vollmer, Nicolas Pietrancosta, Leiv Sigve Håvarstein, André Zapun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e8f7d6353d84e29a4d53b28f4a9d9e8
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spelling	oai:doaj.org-article:4e8f7d6353d84e29a4d53b28f4a9d9e82021-12-02T15:33:39ZStructure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae10.1038/s41467-018-05602-w2041-1723https://doaj.org/article/4e8f7d6353d84e29a4d53b28f4a9d9e82018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05602-whttps://doaj.org/toc/2041-1723The amidotransferase MurT/GatD complex catalyzes peptidoglycan precursor amidation in some Gram-positive bacteria. Here the authors present the crystal structure of the Streptococcus pneumoniae MurT/GatD complex and provide mechanistic insights, which are of interest for drug development.Cécile MorlotDaniel StraumeKatharina PetersOlav A. HegnarNolwenn SimonAnne-Marie VillardCarlos Contreras-MartelFrancisco LeisicoEefjan BreukinkChristine Gravier-PelletierLaurent Le CorreWaldemar VollmerNicolas PietrancostaLeiv Sigve HåvarsteinAndré ZapunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cécile Morlot Daniel Straume Katharina Peters Olav A. Hegnar Nolwenn Simon Anne-Marie Villard Carlos Contreras-Martel Francisco Leisico Eefjan Breukink Christine Gravier-Pelletier Laurent Le Corre Waldemar Vollmer Nicolas Pietrancosta Leiv Sigve Håvarstein André Zapun Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
description	The amidotransferase MurT/GatD complex catalyzes peptidoglycan precursor amidation in some Gram-positive bacteria. Here the authors present the crystal structure of the Streptococcus pneumoniae MurT/GatD complex and provide mechanistic insights, which are of interest for drug development.
format	article
author	Cécile Morlot Daniel Straume Katharina Peters Olav A. Hegnar Nolwenn Simon Anne-Marie Villard Carlos Contreras-Martel Francisco Leisico Eefjan Breukink Christine Gravier-Pelletier Laurent Le Corre Waldemar Vollmer Nicolas Pietrancosta Leiv Sigve Håvarstein André Zapun
author_facet	Cécile Morlot Daniel Straume Katharina Peters Olav A. Hegnar Nolwenn Simon Anne-Marie Villard Carlos Contreras-Martel Francisco Leisico Eefjan Breukink Christine Gravier-Pelletier Laurent Le Corre Waldemar Vollmer Nicolas Pietrancosta Leiv Sigve Håvarstein André Zapun
author_sort	Cécile Morlot
title	Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_short	Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_full	Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_fullStr	Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_full_unstemmed	Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_sort	structure of the essential peptidoglycan amidotransferase murt/gatd complex from streptococcus pneumoniae
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4e8f7d6353d84e29a4d53b28f4a9d9e8
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Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

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