EFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

Objective: To determine the efficacy of induction chemotherapy in locally advanced squamous cell carcinoma of head and neck. Study Design: Descriptive case series. Place and Duration of Study: This study was conducted at the Department of Oncology, Combined Military Hospital (CMH) Rawalpindi,...

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Autores principales:	Muhammad Imran Khan Wajid, Usman Ali, Umair Aslam Shahzad Khan, Shahid Rasul, Ahsan Mahmood, Salman Arif
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	squamous cell carcinoma induction chemotherapy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4e9162f73c7b4aabaf8d38a63e9abf41
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spelling	oai:doaj.org-article:4e9162f73c7b4aabaf8d38a63e9abf412021-11-12T05:07:59ZEFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK0030-96482411-8842https://doaj.org/article/4e9162f73c7b4aabaf8d38a63e9abf412019-04-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2729/2137https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the efficacy of induction chemotherapy in locally advanced squamous cell carcinoma of head and neck. Study Design: Descriptive case series. Place and Duration of Study: This study was conducted at the Department of Oncology, Combined Military Hospital (CMH) Rawalpindi, from Feb 2016 to Aug 2016 over a period of 6 months. Material and Methods: Fifty five patients of both genders, having ages 12-65 years with confirmed histopathological diagnosis of squamous cell carcinoma of head and neck region with clinical and radiological stage III to stage IVB were included in this study. The patients fulfilling the inclusion criteria were planned to receive 3 cycles of induction chemotherapy and were evaluated after 4 weeks for response assessment. The collected data was analyzed by using SPSS version 17. Results: Among fifty five patients with Head and Neck Squamous Cell Carcinoma (HNSCC) 34 (62%) patients showed efficacy more than 50%, while, 21 (38%) had no response. Higher efficacy was noted in patients of younger age, male gender, those who were married, with higher literacy level and better socioeconomic status. Higher efficacy was also observed in the patients who had been having HNSCC of less than 12 months (p=0.0031). On univariate analysis, the prognostic factors significantly affecting progression-free survival were marital status and duration of illness. Conclusions: The efficacy of induction chemotherapy in locally advanced squamous cell carcinoma of head and neck is encouraging and needs further validation through more detailed multicenter trials.Muhammad Imran Khan WajidUsman AliUmair Aslam Shahzad KhanShahid RasulAhsan MahmoodSalman ArifArmy Medical College Rawalpindiarticlesquamous cell carcinomainduction chemotherapyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 2, Pp 236-240 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	squamous cell carcinoma induction chemotherapy Medicine R Medicine (General) R5-920
spellingShingle	squamous cell carcinoma induction chemotherapy Medicine R Medicine (General) R5-920 Muhammad Imran Khan Wajid Usman Ali Umair Aslam Shahzad Khan Shahid Rasul Ahsan Mahmood Salman Arif EFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK
description	Objective: To determine the efficacy of induction chemotherapy in locally advanced squamous cell carcinoma of head and neck. Study Design: Descriptive case series. Place and Duration of Study: This study was conducted at the Department of Oncology, Combined Military Hospital (CMH) Rawalpindi, from Feb 2016 to Aug 2016 over a period of 6 months. Material and Methods: Fifty five patients of both genders, having ages 12-65 years with confirmed histopathological diagnosis of squamous cell carcinoma of head and neck region with clinical and radiological stage III to stage IVB were included in this study. The patients fulfilling the inclusion criteria were planned to receive 3 cycles of induction chemotherapy and were evaluated after 4 weeks for response assessment. The collected data was analyzed by using SPSS version 17. Results: Among fifty five patients with Head and Neck Squamous Cell Carcinoma (HNSCC) 34 (62%) patients showed efficacy more than 50%, while, 21 (38%) had no response. Higher efficacy was noted in patients of younger age, male gender, those who were married, with higher literacy level and better socioeconomic status. Higher efficacy was also observed in the patients who had been having HNSCC of less than 12 months (p=0.0031). On univariate analysis, the prognostic factors significantly affecting progression-free survival were marital status and duration of illness. Conclusions: The efficacy of induction chemotherapy in locally advanced squamous cell carcinoma of head and neck is encouraging and needs further validation through more detailed multicenter trials.
format	article
author	Muhammad Imran Khan Wajid Usman Ali Umair Aslam Shahzad Khan Shahid Rasul Ahsan Mahmood Salman Arif
author_facet	Muhammad Imran Khan Wajid Usman Ali Umair Aslam Shahzad Khan Shahid Rasul Ahsan Mahmood Salman Arif
author_sort	Muhammad Imran Khan Wajid
title	EFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK
title_short	EFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK
title_full	EFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK
title_fullStr	EFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK
title_full_unstemmed	EFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK
title_sort	efficacy of induction chemotherapy in locally advanced squamous cell carcinoma of head and neck
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/4e9162f73c7b4aabaf8d38a63e9abf41
work_keys_str_mv	AT muhammadimrankhanwajid efficacyofinductionchemotherapyinlocallyadvancedsquamouscellcarcinomaofheadandneck AT usmanali efficacyofinductionchemotherapyinlocallyadvancedsquamouscellcarcinomaofheadandneck AT umairaslamshahzadkhan efficacyofinductionchemotherapyinlocallyadvancedsquamouscellcarcinomaofheadandneck AT shahidrasul efficacyofinductionchemotherapyinlocallyadvancedsquamouscellcarcinomaofheadandneck AT ahsanmahmood efficacyofinductionchemotherapyinlocallyadvancedsquamouscellcarcinomaofheadandneck AT salmanarif efficacyofinductionchemotherapyinlocallyadvancedsquamouscellcarcinomaofheadandneck
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EFFICACY OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

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