Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.

Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation. The purpose of this study is to investigate whether IOP can help to reduce acute endo...

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Autores principales: Binhong Hu, Yuqing Dong, Wenjing Zhou, Yichuan Ma, Luyao Li, Xianhua Fu, Wenxuan Zhang, Yuanyue Luo, Jingyu Pu, Xin Deng, Rong Zhang, Songqing Liu
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Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/4e91c7a844be4aa5b8ecbe347099635e
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spelling oai:doaj.org-article:4e91c7a844be4aa5b8ecbe347099635e2021-12-02T20:06:02ZEffect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.1932-620310.1371/journal.pone.0259570https://doaj.org/article/4e91c7a844be4aa5b8ecbe347099635e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259570https://doaj.org/toc/1932-6203Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation. The purpose of this study is to investigate whether IOP can help to reduce acute endometritis by regulating intestinal flora. We observed pathological changes in mice with endometritis following treatment with IOP and evaluated changes in the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), and further studied the effects of IOP on the intestinal flora of endometritis mice using 16S rRNA high-throughput sequencing. The results showed that IOP improved the condition of uterine tissues and reduced the release of pro-inflammatory cytokines. Meanwhile, the 16S rRNA sequencing results showed that IOP could regulate the changes in intestinal microflora at the level of genera, possibly by changing the relative abundance of some genera.Binhong HuYuqing DongWenjing ZhouYichuan MaLuyao LiXianhua FuWenxuan ZhangYuanyue LuoJingyu PuXin DengRong ZhangSongqing LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259570 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Binhong Hu
Yuqing Dong
Wenjing Zhou
Yichuan Ma
Luyao Li
Xianhua Fu
Wenxuan Zhang
Yuanyue Luo
Jingyu Pu
Xin Deng
Rong Zhang
Songqing Liu
Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.
description Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation. The purpose of this study is to investigate whether IOP can help to reduce acute endometritis by regulating intestinal flora. We observed pathological changes in mice with endometritis following treatment with IOP and evaluated changes in the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), and further studied the effects of IOP on the intestinal flora of endometritis mice using 16S rRNA high-throughput sequencing. The results showed that IOP improved the condition of uterine tissues and reduced the release of pro-inflammatory cytokines. Meanwhile, the 16S rRNA sequencing results showed that IOP could regulate the changes in intestinal microflora at the level of genera, possibly by changing the relative abundance of some genera.
format article
author Binhong Hu
Yuqing Dong
Wenjing Zhou
Yichuan Ma
Luyao Li
Xianhua Fu
Wenxuan Zhang
Yuanyue Luo
Jingyu Pu
Xin Deng
Rong Zhang
Songqing Liu
author_facet Binhong Hu
Yuqing Dong
Wenjing Zhou
Yichuan Ma
Luyao Li
Xianhua Fu
Wenxuan Zhang
Yuanyue Luo
Jingyu Pu
Xin Deng
Rong Zhang
Songqing Liu
author_sort Binhong Hu
title Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.
title_short Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.
title_full Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.
title_fullStr Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.
title_full_unstemmed Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.
title_sort effect of inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/4e91c7a844be4aa5b8ecbe347099635e
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