Emerging options for the management of age-related macular degeneration with stem cells

Ingrid Mooney1, James LaMotte21Eye Design, Santa Fe, NM, USA; 2Department of Basic and Visual Science, Southern California College of Optometry, Fullerton, CA, USAAbstract: Age-related macular degeneration (AMD) is a devastating retinal disease that occurs in later life as the retinal pigment epithe...

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Autores principales:	Ingrid Mooney, James LaMotte
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/4e921069d34745c8a786e6c0caa10df1
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id	oai:doaj.org-article:4e921069d34745c8a786e6c0caa10df1
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spelling	oai:doaj.org-article:4e921069d34745c8a786e6c0caa10df12021-12-02T00:22:25ZEmerging options for the management of age-related macular degeneration with stem cells1178-6957https://doaj.org/article/4e921069d34745c8a786e6c0caa10df12010-12-01T00:00:00Zhttp://www.dovepress.com/emerging-options-for-the-management-of-age-related-macular-degeneratio-a5947https://doaj.org/toc/1178-6957Ingrid Mooney1, James LaMotte21Eye Design, Santa Fe, NM, USA; 2Department of Basic and Visual Science, Southern California College of Optometry, Fullerton, CA, USAAbstract: Age-related macular degeneration (AMD) is a devastating retinal disease that occurs in later life as the retinal pigment epithelium (RPE) cells die, with subsequent photoreceptor degeneration. In the past, RPE transplant surgeries gave evidence that AMD was potentially treatable, but it involved limited amounts of ocular tissue, and the complication rate was high. Then, stem cell transplants offered an unlimited supply of retinal precursors for endogenous repair and exogenous cell replacement. Debate continues as to which type of stem cell is most appropriate for treating AMD. The prospects include adult-derived progenitor stem cells (including progenitor cells from ocular tissues), hematopoietic stem cells, embryonic stem cells, and induced pluripotent stem cells. Now the therapy is expanding into phase I human trials. This review examines the collective research contributions toward a clinical model of AMD management with stem cells.Keywords: age-related macular degeneration, pluripotent stem cells, stem cells, transplantation, retinal pigmented epithelium&nbsp; Ingrid MooneyJames LaMotteDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2011, Iss default, Pp 1-10 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Ingrid Mooney James LaMotte Emerging options for the management of age-related macular degeneration with stem cells
description	Ingrid Mooney1, James LaMotte21Eye Design, Santa Fe, NM, USA; 2Department of Basic and Visual Science, Southern California College of Optometry, Fullerton, CA, USAAbstract: Age-related macular degeneration (AMD) is a devastating retinal disease that occurs in later life as the retinal pigment epithelium (RPE) cells die, with subsequent photoreceptor degeneration. In the past, RPE transplant surgeries gave evidence that AMD was potentially treatable, but it involved limited amounts of ocular tissue, and the complication rate was high. Then, stem cell transplants offered an unlimited supply of retinal precursors for endogenous repair and exogenous cell replacement. Debate continues as to which type of stem cell is most appropriate for treating AMD. The prospects include adult-derived progenitor stem cells (including progenitor cells from ocular tissues), hematopoietic stem cells, embryonic stem cells, and induced pluripotent stem cells. Now the therapy is expanding into phase I human trials. This review examines the collective research contributions toward a clinical model of AMD management with stem cells.Keywords: age-related macular degeneration, pluripotent stem cells, stem cells, transplantation, retinal pigmented epithelium&nbsp;
format	article
author	Ingrid Mooney James LaMotte
author_facet	Ingrid Mooney James LaMotte
author_sort	Ingrid Mooney
title	Emerging options for the management of age-related macular degeneration with stem cells
title_short	Emerging options for the management of age-related macular degeneration with stem cells
title_full	Emerging options for the management of age-related macular degeneration with stem cells
title_fullStr	Emerging options for the management of age-related macular degeneration with stem cells
title_full_unstemmed	Emerging options for the management of age-related macular degeneration with stem cells
title_sort	emerging options for the management of age-related macular degeneration with stem cells
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/4e921069d34745c8a786e6c0caa10df1
work_keys_str_mv	AT ingridmooney emergingoptionsforthemanagementofagerelatedmaculardegenerationwithstemcells AT jameslamotte emergingoptionsforthemanagementofagerelatedmaculardegenerationwithstemcells
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Emerging options for the management of age-related macular degeneration with stem cells

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