Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes

(1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extrace...

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Autores principales:	Cristian-Ene Roată, Ștefan Iacob, Ștefan Morărașu, Cristian Livadaru, Ionuț Tudorancea, Sorinel Luncă, Mihail-Gabriel Dimofte
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	collagen nanoparticles theranostics Crystallography QD901-999
Acceso en línea:	https://doaj.org/article/4e94c3cc0dd44312bde1f4d249bf4401
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spelling	oai:doaj.org-article:4e94c3cc0dd44312bde1f4d249bf44012021-11-25T17:19:20ZCollagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes10.3390/cryst111113962073-4352https://doaj.org/article/4e94c3cc0dd44312bde1f4d249bf44012021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4352/11/11/1396https://doaj.org/toc/2073-4352(1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extracellular matrix. (2) Methods: We performed a scoping review of studies that analyzed the binding capacity of collagen-targeting nanoparticles. The search algorithm and inclusion criteria were based on PRISMA and ARRIVE guidelines. (3) Results: Fourteen studies matched all the inclusion criteria. All studies analyzed the distribution of nanoparticles in the collagen matrix, either by using collagen-targeting nanoparticles or by using unmodified ones. Most studies used collagen-binding nanoparticles for vascular research to target sites of endothelial injury, atherosclerotic plaques, or myocardial infarction. Two studies targeted the exposed collagen in models of liver fibrosis. (4) Conclusions: Our review summarizes the current literature on the methods and outcomes of using nanoparticles to target collagen. The studies reveal that there is high applicability for collagen-binding nanoparticles in cardiac or hepatic pathology and they could prove useful for targeted therapy of neoplastic lesions, which show an abundance of stromal collagen.Cristian-Ene RoatăȘtefan IacobȘtefan MorărașuCristian LivadaruIonuț TudoranceaSorinel LuncăMihail-Gabriel DimofteMDPI AGarticlecollagennanoparticlestheranosticsCrystallographyQD901-999ENCrystals, Vol 11, Iss 1396, p 1396 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	collagen nanoparticles theranostics Crystallography QD901-999
spellingShingle	collagen nanoparticles theranostics Crystallography QD901-999 Cristian-Ene Roată Ștefan Iacob Ștefan Morărașu Cristian Livadaru Ionuț Tudorancea Sorinel Luncă Mihail-Gabriel Dimofte Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes
description	(1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extracellular matrix. (2) Methods: We performed a scoping review of studies that analyzed the binding capacity of collagen-targeting nanoparticles. The search algorithm and inclusion criteria were based on PRISMA and ARRIVE guidelines. (3) Results: Fourteen studies matched all the inclusion criteria. All studies analyzed the distribution of nanoparticles in the collagen matrix, either by using collagen-targeting nanoparticles or by using unmodified ones. Most studies used collagen-binding nanoparticles for vascular research to target sites of endothelial injury, atherosclerotic plaques, or myocardial infarction. Two studies targeted the exposed collagen in models of liver fibrosis. (4) Conclusions: Our review summarizes the current literature on the methods and outcomes of using nanoparticles to target collagen. The studies reveal that there is high applicability for collagen-binding nanoparticles in cardiac or hepatic pathology and they could prove useful for targeted therapy of neoplastic lesions, which show an abundance of stromal collagen.
format	article
author	Cristian-Ene Roată Ștefan Iacob Ștefan Morărașu Cristian Livadaru Ionuț Tudorancea Sorinel Luncă Mihail-Gabriel Dimofte
author_facet	Cristian-Ene Roată Ștefan Iacob Ștefan Morărașu Cristian Livadaru Ionuț Tudorancea Sorinel Luncă Mihail-Gabriel Dimofte
author_sort	Cristian-Ene Roată
title	Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes
title_short	Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes
title_full	Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes
title_fullStr	Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes
title_full_unstemmed	Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes
title_sort	collagen-binding nanoparticles: a scoping review of methods and outcomes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4e94c3cc0dd44312bde1f4d249bf4401
work_keys_str_mv	AT cristianeneroata collagenbindingnanoparticlesascopingreviewofmethodsandoutcomes AT stefaniacob collagenbindingnanoparticlesascopingreviewofmethodsandoutcomes AT stefanmorarasu collagenbindingnanoparticlesascopingreviewofmethodsandoutcomes AT cristianlivadaru collagenbindingnanoparticlesascopingreviewofmethodsandoutcomes AT ionuttudorancea collagenbindingnanoparticlesascopingreviewofmethodsandoutcomes AT sorinellunca collagenbindingnanoparticlesascopingreviewofmethodsandoutcomes AT mihailgabrieldimofte collagenbindingnanoparticlesascopingreviewofmethodsandoutcomes
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Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes

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