Energy restriction during childhood and early adulthood and ovarian cancer risk.

Dietary energy restriction may protect against cancer. In parts of The Netherlands, mostly in larger cities, periods of chronically impaired nutrition and even severe famine (Hunger Winter 1944-1945) existed during the 1930s and World War II (1940-1945). We studied the association between energy res...

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Autores principales:	Leo J Schouten, Boukje A C van Dijk, L H Lumey, R Alexandra Goldbohm, Piet A van den Brandt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4e95ff9aa932468ba6ff57cb4516d8b7
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id	oai:doaj.org-article:4e95ff9aa932468ba6ff57cb4516d8b7
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spelling	oai:doaj.org-article:4e95ff9aa932468ba6ff57cb4516d8b72021-11-18T07:33:37ZEnergy restriction during childhood and early adulthood and ovarian cancer risk.1932-620310.1371/journal.pone.0027960https://doaj.org/article/4e95ff9aa932468ba6ff57cb4516d8b72011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22132180/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Dietary energy restriction may protect against cancer. In parts of The Netherlands, mostly in larger cities, periods of chronically impaired nutrition and even severe famine (Hunger Winter 1944-1945) existed during the 1930s and World War II (1940-1945). We studied the association between energy restriction during childhood and early adulthood on the risk of ovarian cancer later in life. In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women aged 55-69 years at baseline. Follow-up for cancer was established by record linkage to the Netherlands Cancer Registry. After 16.3 years of follow-up, 364 invasive epithelial ovarian cancer cases and 2220 subcohort members (sampled from the total cohort directly after baseline) with complete information confounders were available for case-cohort analyses. In multivariable analysis, ovarian cancer risk was lower for participants with an unemployed father during the 1930s (Hazard Ratio (HR), 0.70; 95% Confidence Interval (CI), 0.47-1.06) compared to participants with an employed father as well as for participants living in a city during World War II (HR, 0.69; 95% CI, 0.54-0.90) compared to participants living in the country-side. Residence in a Western City during the famine (Hunger Winter) was not associated with a decreased risk. Our results show a relation between proxy variables for modest energy restriction over a longer period of time during childhood or early adulthood and a reduced ovarian cancer risk.Leo J SchoutenBoukje A C van DijkL H LumeyR Alexandra GoldbohmPiet A van den BrandtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27960 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leo J Schouten Boukje A C van Dijk L H Lumey R Alexandra Goldbohm Piet A van den Brandt Energy restriction during childhood and early adulthood and ovarian cancer risk.
description	Dietary energy restriction may protect against cancer. In parts of The Netherlands, mostly in larger cities, periods of chronically impaired nutrition and even severe famine (Hunger Winter 1944-1945) existed during the 1930s and World War II (1940-1945). We studied the association between energy restriction during childhood and early adulthood on the risk of ovarian cancer later in life. In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women aged 55-69 years at baseline. Follow-up for cancer was established by record linkage to the Netherlands Cancer Registry. After 16.3 years of follow-up, 364 invasive epithelial ovarian cancer cases and 2220 subcohort members (sampled from the total cohort directly after baseline) with complete information confounders were available for case-cohort analyses. In multivariable analysis, ovarian cancer risk was lower for participants with an unemployed father during the 1930s (Hazard Ratio (HR), 0.70; 95% Confidence Interval (CI), 0.47-1.06) compared to participants with an employed father as well as for participants living in a city during World War II (HR, 0.69; 95% CI, 0.54-0.90) compared to participants living in the country-side. Residence in a Western City during the famine (Hunger Winter) was not associated with a decreased risk. Our results show a relation between proxy variables for modest energy restriction over a longer period of time during childhood or early adulthood and a reduced ovarian cancer risk.
format	article
author	Leo J Schouten Boukje A C van Dijk L H Lumey R Alexandra Goldbohm Piet A van den Brandt
author_facet	Leo J Schouten Boukje A C van Dijk L H Lumey R Alexandra Goldbohm Piet A van den Brandt
author_sort	Leo J Schouten
title	Energy restriction during childhood and early adulthood and ovarian cancer risk.
title_short	Energy restriction during childhood and early adulthood and ovarian cancer risk.
title_full	Energy restriction during childhood and early adulthood and ovarian cancer risk.
title_fullStr	Energy restriction during childhood and early adulthood and ovarian cancer risk.
title_full_unstemmed	Energy restriction during childhood and early adulthood and ovarian cancer risk.
title_sort	energy restriction during childhood and early adulthood and ovarian cancer risk.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4e95ff9aa932468ba6ff57cb4516d8b7
work_keys_str_mv	AT leojschouten energyrestrictionduringchildhoodandearlyadulthoodandovariancancerrisk AT boukjeacvandijk energyrestrictionduringchildhoodandearlyadulthoodandovariancancerrisk AT lhlumey energyrestrictionduringchildhoodandearlyadulthoodandovariancancerrisk AT ralexandragoldbohm energyrestrictionduringchildhoodandearlyadulthoodandovariancancerrisk AT pietavandenbrandt energyrestrictionduringchildhoodandearlyadulthoodandovariancancerrisk
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Energy restriction during childhood and early adulthood and ovarian cancer risk.

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