Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence

Mitochondria are one of organelles that undergo significant changes associated with senescence. An increase in mitochondrial size is observed in senescent cells, and this increase is ascribed to the accumulation of dysfunctional mitochondria that generate excessive reactive oxygen species (ROS). Suc...

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Autores principales:	Yun Haeng Lee, Ji Yun Park, Haneur Lee, Eun Seon Song, Myeong Uk Kuk, Junghyun Joo, Sekyung Oh, Hyung Wook Kwon, Joon Tae Park, Sang Chul Park
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mitochondrial metabolic reprogramming mitochondria ROS senescence amelioration Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4e96e9a99cc243098ba18136314fbdac
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spelling	oai:doaj.org-article:4e96e9a99cc243098ba18136314fbdac2021-11-25T17:10:17ZTargeting Mitochondrial Metabolism as a Strategy to Treat Senescence10.3390/cells101130032073-4409https://doaj.org/article/4e96e9a99cc243098ba18136314fbdac2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3003https://doaj.org/toc/2073-4409Mitochondria are one of organelles that undergo significant changes associated with senescence. An increase in mitochondrial size is observed in senescent cells, and this increase is ascribed to the accumulation of dysfunctional mitochondria that generate excessive reactive oxygen species (ROS). Such dysfunctional mitochondria are prime targets for ROS-induced damage, which leads to the deterioration of oxidative phosphorylation and increased dependence on glycolysis as an energy source. Based on findings indicating that senescent cells exhibit mitochondrial metabolic alterations, a strategy to induce mitochondrial metabolic reprogramming has been proposed to treat aging and age-related diseases. In this review, we discuss senescence-related mitochondrial changes and consequent mitochondrial metabolic alterations. We assess the significance of mitochondrial metabolic reprogramming for senescence regulation and propose the appropriate control of mitochondrial metabolism to ameliorate senescence. Learning how to regulate mitochondrial metabolism will provide knowledge for the control of aging and age-related pathologies. Further research focusing on mitochondrial metabolic reprogramming will be an important guide for the development of anti-aging therapies, and will provide novel strategies for anti-aging interventions.Yun Haeng LeeJi Yun ParkHaneur LeeEun Seon SongMyeong Uk KukJunghyun JooSekyung OhHyung Wook KwonJoon Tae ParkSang Chul ParkMDPI AGarticlemitochondrial metabolic reprogrammingmitochondriaROSsenescence ameliorationBiology (General)QH301-705.5ENCells, Vol 10, Iss 3003, p 3003 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondrial metabolic reprogramming mitochondria ROS senescence amelioration Biology (General) QH301-705.5
spellingShingle	mitochondrial metabolic reprogramming mitochondria ROS senescence amelioration Biology (General) QH301-705.5 Yun Haeng Lee Ji Yun Park Haneur Lee Eun Seon Song Myeong Uk Kuk Junghyun Joo Sekyung Oh Hyung Wook Kwon Joon Tae Park Sang Chul Park Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence
description	Mitochondria are one of organelles that undergo significant changes associated with senescence. An increase in mitochondrial size is observed in senescent cells, and this increase is ascribed to the accumulation of dysfunctional mitochondria that generate excessive reactive oxygen species (ROS). Such dysfunctional mitochondria are prime targets for ROS-induced damage, which leads to the deterioration of oxidative phosphorylation and increased dependence on glycolysis as an energy source. Based on findings indicating that senescent cells exhibit mitochondrial metabolic alterations, a strategy to induce mitochondrial metabolic reprogramming has been proposed to treat aging and age-related diseases. In this review, we discuss senescence-related mitochondrial changes and consequent mitochondrial metabolic alterations. We assess the significance of mitochondrial metabolic reprogramming for senescence regulation and propose the appropriate control of mitochondrial metabolism to ameliorate senescence. Learning how to regulate mitochondrial metabolism will provide knowledge for the control of aging and age-related pathologies. Further research focusing on mitochondrial metabolic reprogramming will be an important guide for the development of anti-aging therapies, and will provide novel strategies for anti-aging interventions.
format	article
author	Yun Haeng Lee Ji Yun Park Haneur Lee Eun Seon Song Myeong Uk Kuk Junghyun Joo Sekyung Oh Hyung Wook Kwon Joon Tae Park Sang Chul Park
author_facet	Yun Haeng Lee Ji Yun Park Haneur Lee Eun Seon Song Myeong Uk Kuk Junghyun Joo Sekyung Oh Hyung Wook Kwon Joon Tae Park Sang Chul Park
author_sort	Yun Haeng Lee
title	Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence
title_short	Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence
title_full	Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence
title_fullStr	Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence
title_full_unstemmed	Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence
title_sort	targeting mitochondrial metabolism as a strategy to treat senescence
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4e96e9a99cc243098ba18136314fbdac
work_keys_str_mv	AT yunhaenglee targetingmitochondrialmetabolismasastrategytotreatsenescence AT jiyunpark targetingmitochondrialmetabolismasastrategytotreatsenescence AT haneurlee targetingmitochondrialmetabolismasastrategytotreatsenescence AT eunseonsong targetingmitochondrialmetabolismasastrategytotreatsenescence AT myeongukkuk targetingmitochondrialmetabolismasastrategytotreatsenescence AT junghyunjoo targetingmitochondrialmetabolismasastrategytotreatsenescence AT sekyungoh targetingmitochondrialmetabolismasastrategytotreatsenescence AT hyungwookkwon targetingmitochondrialmetabolismasastrategytotreatsenescence AT joontaepark targetingmitochondrialmetabolismasastrategytotreatsenescence AT sangchulpark targetingmitochondrialmetabolismasastrategytotreatsenescence
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Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence

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