Lower cognitive function in patients with age-related macular degeneration: a meta-analysis

Li-Xiao Zhou,1 Cheng-Lin Sun,1 Li-Juan Wei,1 Zhi-Min Gu,1 Liang Lv,1 Yalong Dang21Department of Ophthalmology, The Fifth Affiliated Hospital of Zhengzhou University, 2Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of&nbs...

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Autores principales:	Zhou LX, Sun CL, Wei LJ, Gu ZM, Lv L, Dang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Age-related Macular Degeneration Cognitive impairment Meta- analysis Minimum Mental State Examination Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/4e97d04f12f742f4996e9b3d723f1266
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spelling	oai:doaj.org-article:4e97d04f12f742f4996e9b3d723f12662021-12-02T00:06:45ZLower cognitive function in patients with age-related macular degeneration: a meta-analysis1178-1998https://doaj.org/article/4e97d04f12f742f4996e9b3d723f12662016-02-01T00:00:00Zhttps://www.dovepress.com/lower-cognitive-function-in-patients-with-age-related-macular-degenera-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Li-Xiao Zhou,1 Cheng-Lin Sun,1 Li-Juan Wei,1 Zhi-Min Gu,1 Liang Lv,1 Yalong Dang21Department of Ophthalmology, The Fifth Affiliated Hospital of Zhengzhou University, 2Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaObjective: To investigate the cognitive impairment in patients with age-related macular degeneration (AMD).Methods: Relevant articles were identified through a search of the following electronic databases through October 2015, without language restriction: 1) PubMed; 2) the Cochrane Library; 3) EMBASE; 4) ScienceDirect. Meta-analysis was conducted using STATA 12.0 software. Standardized mean differences with corresponding 95% confidence intervals were calculated. All of the included studies met the following four criteria: 1) the study design was a case–control or randomized controlled trial (RCT) study; 2) the study investigated cognitive function in the patient with AMD; 3) the diagnoses of AMD must be provided; 4) there were sufficient scores data to extract for evaluating cognitive function between cases and controls. The Newcastle–Ottawa Scale criteria were used to assess the methodological quality of the studies.Results: Of the initial 278 literatures, only six case–control and one RCT studies met all of the inclusion criteria. A total of 794 AMD patients and 1,227 controls were included in this study. Five studies were performed with mini-mental state examination (MMSE), two studies with animal fluency, two studies with trail making test (TMT)-A and -B, one study with Mini-Cog. Results of the meta-analysis revealed lower cognitive function test scores in patients with AMD, especially with MMSE and Mini-Cog test (P≤0.001 for all). The results also showed that differences in the TMT-A (except AMD [total] vs controls) and TMT-B test had no statistical significance (P>0.01). The Newcastle–Ottawa Scale score was ≥5 for all of the included studies. Based on the sensitivity analysis, no single study influenced the overall pooled estimates.Conclusion: This meta-analysis suggests lower cognitive function test scores in patients with AMD, especially with MMSE and Mini-Cog test. The other cognitive impairment screening tests, such as animal fluency test and TMT, need more studies to assess.Keywords: age-related macular degeneration; cognitive impairment; meta-analysis; mini mental state examinationZhou LXSun CLWei LJGu ZMLv LDang YDove Medical PressarticleAge-related Macular DegenerationCognitive impairmentMeta- analysisMinimum Mental State ExaminationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 215-223 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Age-related Macular Degeneration Cognitive impairment Meta- analysis Minimum Mental State Examination Geriatrics RC952-954.6
spellingShingle	Age-related Macular Degeneration Cognitive impairment Meta- analysis Minimum Mental State Examination Geriatrics RC952-954.6 Zhou LX Sun CL Wei LJ Gu ZM Lv L Dang Y Lower cognitive function in patients with age-related macular degeneration: a meta-analysis
description	Li-Xiao Zhou,1 Cheng-Lin Sun,1 Li-Juan Wei,1 Zhi-Min Gu,1 Liang Lv,1 Yalong Dang21Department of Ophthalmology, The Fifth Affiliated Hospital of Zhengzhou University, 2Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaObjective: To investigate the cognitive impairment in patients with age-related macular degeneration (AMD).Methods: Relevant articles were identified through a search of the following electronic databases through October 2015, without language restriction: 1) PubMed; 2) the Cochrane Library; 3) EMBASE; 4) ScienceDirect. Meta-analysis was conducted using STATA 12.0 software. Standardized mean differences with corresponding 95% confidence intervals were calculated. All of the included studies met the following four criteria: 1) the study design was a case–control or randomized controlled trial (RCT) study; 2) the study investigated cognitive function in the patient with AMD; 3) the diagnoses of AMD must be provided; 4) there were sufficient scores data to extract for evaluating cognitive function between cases and controls. The Newcastle–Ottawa Scale criteria were used to assess the methodological quality of the studies.Results: Of the initial 278 literatures, only six case–control and one RCT studies met all of the inclusion criteria. A total of 794 AMD patients and 1,227 controls were included in this study. Five studies were performed with mini-mental state examination (MMSE), two studies with animal fluency, two studies with trail making test (TMT)-A and -B, one study with Mini-Cog. Results of the meta-analysis revealed lower cognitive function test scores in patients with AMD, especially with MMSE and Mini-Cog test (P≤0.001 for all). The results also showed that differences in the TMT-A (except AMD [total] vs controls) and TMT-B test had no statistical significance (P>0.01). The Newcastle–Ottawa Scale score was ≥5 for all of the included studies. Based on the sensitivity analysis, no single study influenced the overall pooled estimates.Conclusion: This meta-analysis suggests lower cognitive function test scores in patients with AMD, especially with MMSE and Mini-Cog test. The other cognitive impairment screening tests, such as animal fluency test and TMT, need more studies to assess.Keywords: age-related macular degeneration; cognitive impairment; meta-analysis; mini mental state examination
format	article
author	Zhou LX Sun CL Wei LJ Gu ZM Lv L Dang Y
author_facet	Zhou LX Sun CL Wei LJ Gu ZM Lv L Dang Y
author_sort	Zhou LX
title	Lower cognitive function in patients with age-related macular degeneration: a meta-analysis
title_short	Lower cognitive function in patients with age-related macular degeneration: a meta-analysis
title_full	Lower cognitive function in patients with age-related macular degeneration: a meta-analysis
title_fullStr	Lower cognitive function in patients with age-related macular degeneration: a meta-analysis
title_full_unstemmed	Lower cognitive function in patients with age-related macular degeneration: a meta-analysis
title_sort	lower cognitive function in patients with age-related macular degeneration: a meta-analysis
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4e97d04f12f742f4996e9b3d723f1266
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Lower cognitive function in patients with age-related macular degeneration: a meta-analysis

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